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Active FLT3 [plasma membrane]
Stable Identifier
R-BTA-9604751
Type
Complex
Species
Bos taurus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Active FLT3 binds to GRAP2 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:GRAP2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to GRB10 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:GRB10 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 phosphorylates CDKN1B (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:GRB2 binds SOS1 (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)
active FLT3:p-Y GRB10 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
FLT3 phosphorylates GRB10 (Bos taurus)
active FLT3:GRB10 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
FLT3 signaling through SRC family kinases (Bos taurus)
Active FLT3 binds to LCK (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:LCK [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SYK (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SYK [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
Active FLT3 binds to ABL2 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:ABL2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to CBL (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:CBL [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SH2B3 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SLA [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SLA2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to CSK (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:CSK [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SH2B3 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SH2B3 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SLA (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SLA [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SLA2 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SLA2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SOCS2 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SOCS2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Active FLT3 binds to SOCS6 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SOCS6 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
FLT3 phosphorylates CBL (Bos taurus)
active FLT3:CBL [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:pY-CBL [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Ubiquitination of FLT3 (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
FLT3 E3 ubiquitin ligases [plasma membrane] (Bos taurus)
active FLT3:SOCS2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:SOCS6 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
active FLT3:pY-CBL [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Signal Transduction (Bos taurus)
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
PI3K phosphorylates PIP2 to PIP3 (Bos taurus)
Activator:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF/MAP kinase cascade (Bos taurus)
RAS GEFs promote RAS nucleotide exchange (Bos taurus)
RAS GEFs [plasma membrane] (Bos taurus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by Insulin receptor (Bos taurus)
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)
PI3K-containing complexes [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Bos taurus)
Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
Active FLT3 [plasma membrane] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
FLT3LG dimer [extracellular region]
(Bos taurus)
x 2
phospho-Autophosphorylated FLT3 [plasma membrane]
(Bos taurus)
Participates
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Bos taurus)
active FLT3:p-Y GRB10 [plasma membrane] (Bos taurus)
active FLT3:CSK [plasma membrane] (Bos taurus)
active FLT3:ABL2 [plasma membrane] (Bos taurus)
active FLT3:pY-CBL [plasma membrane] (Bos taurus)
active FLT3:SOCS6 [plasma membrane] (Bos taurus)
active FLT3:SOCS2 [plasma membrane] (Bos taurus)
active FLT3:SLA2 [plasma membrane] (Bos taurus)
active FLT3:SLA [plasma membrane] (Bos taurus)
active FLT3:SH2B3 [plasma membrane] (Bos taurus)
active FLT3:CBL [plasma membrane] (Bos taurus)
active FLT3:GRAP2 [plasma membrane] (Bos taurus)
active FLT3:LCK [plasma membrane] (Bos taurus)
active FLT3:SYK [plasma membrane] (Bos taurus)
active FLT3:GRB10 [plasma membrane] (Bos taurus)
Active FLT3: GRB2 [plasma membrane] (Bos taurus)
as an input of
Active FLT3 binds to SH2B3 (Bos taurus)
Active FLT3 binds to CSK (Bos taurus)
Active FLT3 binds to SOCS6 (Bos taurus)
Active FLT3 binds to SOCS2 (Bos taurus)
Active FLT3 binds to ABL2 (Bos taurus)
Active FLT3 binds to SLA (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
Active FLT3 binds to SLA2 (Bos taurus)
Ubiquitination of FLT3 (Bos taurus)
Active FLT3 binds to CBL (Bos taurus)
Active FLT3 binds to GRAP2 (Bos taurus)
Active FLT3 binds to LCK (Bos taurus)
Active FLT3 binds to SYK (Bos taurus)
Active FLT3 binds to GRB10 (Bos taurus)
as an output of
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
Inferred From
Active FLT3 [plasma membrane]
(Homo sapiens)
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