Reactome | Active FLT3 binds to GRB10

Active FLT3 binds to GRB10

Stable Identifier

R-HSA-9706308

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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General

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SVG | | PPTX | SBGN

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Growth factor receptor-bound protein 10 (GRB10) can serve as an adaptor linking FLT3 to the p85 subunit of PI3 kinase, and thereby lead to activation of AKT signaling (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
23246379	FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia Kazi, JU, Rönnstrand, L	Mol Oncol	2013
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019