Reactome | Active FLT3 binds to GRB10

Active FLT3 binds to GRB10

Stable Identifier

R-HSA-9706308

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Locations in the PathwayBrowser

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General

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SVG | | PPTX | SBGN

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Growth factor receptor-bound protein 10 (GRB10) can serve as an adaptor linking FLT3 to the p85 subunit of PI3 kinase, and thereby lead to activation of AKT signaling (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
23246379	FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia Kazi, JU, Rönnstrand, L	Mol Oncol	2013