Active FLT3 binds FYN

Stable Identifier
R-HSA-9605259
Type
Reaction [binding]
Species
Homo sapiens
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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Subsequently, tyrosine-protein kinase Fyn (FYN) associates with the phosphorylated residues of fully active FLT3 (Y591, Y599 and pY955) through its SH2 domain (Dosil et al. 1993, Chougule et al. 2016). Experiments confirming this event were performed in mouse cells.

Literature References
PubMed ID Title Journal Year
26848862 FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia

Chougule, RA, Kazi, JU, Rönnstrand, L

Oncotarget 2016
7692230 Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

Dosil, M, Wang, S, Lemischka, IR

Mol. Cell. Biol. 1993
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