Reactome | Active FLT3 [plasma membrane]

Active FLT3 [plasma membrane]

Stable Identifier

R-SSC-9604751

Type

Complex

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3: GRB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3 [plasma membrane] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3: GRB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3 [plasma membrane] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Sus scrofa)
        
        Active FLT3: GRB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3 [plasma membrane] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by Insulin receptor (Sus scrofa)
    - Insulin receptor signalling cascade (Sus scrofa)
      - IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3: GRB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3 [plasma membrane] (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Sus scrofa)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3: GRB2 [plasma membrane] (Sus scrofa)
        
        Active FLT3 [plasma membrane] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

as an input of

as an output of

FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)

Inferred From

Active FLT3 [plasma membrane] (Homo sapiens)