Active FLT3 binds to SOCS6

Stable Identifier
R-HSA-9706330
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The E3 ubiquitin ligase SOCS6 binds to tyrosine phosphorylated FLT3 through Y591 and Y919. SOCS6 contributes to the ubiquitination and degradation of the active FLT3 receptor (Kazi et al, 2012; reviewed in Kazi et al, 2014).

Literature References
PubMed ID Title Journal Year
22952242 Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3

Kazi, JU, Sun, J, Phung, B, Zadjali, F, Flores-Morales, A, Rönnstrand, L

J Biol Chem 2012
24705897 SOCS proteins in regulation of receptor tyrosine kinase signaling

Kazi, JU, Kabir, NN, Flores-Morales, A, Rönnstrand, L

Cell Mol Life Sci 2014
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