The E3 ubiquitin ligase SOCS6 binds to tyrosine phosphorylated FLT3 through Y591 and Y919. SOCS6 contributes to the ubiquitination and degradation of the active FLT3 receptor (Kazi et al, 2012; reviewed in Kazi et al, 2014).
Kazi, JU, Sun, J, Phung, B, Zadjali, F, Flores-Morales, A, Rönnstrand, L
Kazi, JU, Kabir, NN, Flores-Morales, A, Rönnstrand, L
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