Reactome | Active FLT3 binds to SOCS6

Active FLT3 binds to SOCS6

Stable Identifier

R-HSA-9706330

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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The E3 ubiquitin ligase SOCS6 binds to tyrosine phosphorylated FLT3 through Y591 and Y919. SOCS6 contributes to the ubiquitination and degradation of the active FLT3 receptor (Kazi et al, 2012; reviewed in Kazi et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
22952242	Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3 Kazi, JU, Sun, J, Phung, B, Zadjali, F, Flores-Morales, A, Rönnstrand, L	J Biol Chem	2012
24705897	SOCS proteins in regulation of receptor tyrosine kinase signaling Kazi, JU, Kabir, NN, Flores-Morales, A, Rönnstrand, L	Cell Mol Life Sci	2014