Reactome | Active FLT3 binds HCK

Active FLT3 binds HCK

Stable Identifier

R-HSA-9609274

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Tyrosine-protein kinase HCK (HCK) associates with the phosphorylated Y589 and Y591 residues of FLT3. This binding results in further phosphorylation of the FLT3 receptor to make it fully active (Heiss et al. 2006, Mitina et al. 2007). There may be more unknown binding sites for HCK on FLT3.

Literature References

PubMed ID	Title	Journal	Year
16684964	Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 Heiss, E, Masson, K, Sundberg, C, Pedersen, M, Sun, J, Bengtsson, S, Rönnstrand, L	Blood	2006
17668209	Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner Mitina, O, Warmuth, M, Krause, G, Hallek, M, Obermeier, A	Ann. Hematol.	2007

Participants

Input

Output

Active FLT3:HCK [plasma membrane] (Homo sapiens)

Participates

as an event of

FLT3 signaling through SRC family kinases (Homo sapiens)

Inferred From

Active Flt3 binds Hck (Mus musculus)

Authored

Varusai, TM (2019-01-14)

Reviewed

Traer, E (2019-05-03)

Joshi, S (2019-05-21)

Created

Varusai, TM (2018-05-21)

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