Reactome | Active FLT3 binds to SLA2

Active FLT3 binds to SLA2

Stable Identifier

R-HSA-9706323

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SRC-like adaptor protein 2 (SLA2, also known as SLAP2) binds to tyrosine-phosphorylated FLT3 mainly through Y589 and Y591. Binding of SLA2 inhibits downstream signaling through AKT, MAP kinase and the p38 cascades and promotes receptor ubiquitination and internalization (Moharram et al, 2012). Because SLA2 is a known interactor of CBL, it is possible SLA2 indirectly recruits CBL to FLT3 to promote its downregulation, although this has not been explicitly demonstrated (Loreto et al, 2002; Moharram et al, 2012; reviewed in Kazi and Ronnstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
27458164	Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling Kazi, JU, Li, T, Zhao, H, Sun, J, Su, X, Chougule, RA, Moharram, SA, Rönnstrand, L	Oncotarget	2016
12024036	Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling Loreto, MP, Berry, DM, McGlade, CJ	Mol Cell Biol	2002