SRC-like adaptor protein 2 (SLA2, also known as SLAP2) binds to tyrosine-phosphorylated FLT3 mainly through Y589 and Y591. Binding of SLA2 inhibits downstream signaling through AKT, MAP kinase and the p38 cascades and promotes receptor ubiquitination and internalization (Moharram et al, 2012). Because SLA2 is a known interactor of CBL, it is possible SLA2 indirectly recruits CBL to FLT3 to promote its downregulation, although this has not been explicitly demonstrated (Loreto et al, 2002; Moharram et al, 2012; reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Rönnstrand, L
Kazi, JU, Li, T, Zhao, H, Sun, J, Su, X, Chougule, RA, Moharram, SA, Rönnstrand, L
Loreto, MP, Berry, DM, McGlade, CJ
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