Active FLT3 binds to SLA2

Stable Identifier
R-HSA-9706323
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SRC-like adaptor protein 2 (SLA2, also known as SLAP2) binds to tyrosine-phosphorylated FLT3 mainly through Y589 and Y591. Binding of SLA2 inhibits downstream signaling through AKT, MAP kinase and the p38 cascades and promotes receptor ubiquitination and internalization (Moharram et al, 2012). Because SLA2 is a known interactor of CBL, it is possible SLA2 indirectly recruits CBL to FLT3 to promote its downregulation, although this has not been explicitly demonstrated (Loreto et al, 2002; Moharram et al, 2012; reviewed in Kazi and Ronnstrand, 2019).

Literature References
PubMed ID Title Journal Year
27458164 Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

Moharram, SA, Chougule, RA, Su, X, Li, T, Sun, J, Zhao, H, Rönnstrand, L, Kazi, JU

Oncotarget 2016
31066629 FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

Kazi, JU, Rönnstrand, L

Physiol. Rev. 2019
12024036 Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling

Loreto, MP, Berry, DM, McGlade, CJ

Mol Cell Biol 2002
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