Active FLT3 binds to CSK

Stable Identifier
R-HSA-9706298
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Active FLT3 binds to CSK
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The COOH-terminal SRC kinase (CSK) interacts with FLT3 in a phosphorylation-dependent manner through the SH2 domain of CSK. Interaction with CSK downregulates FLT3-dependent signaling through the AKT and MAP kinase pathway without affecting receptor ubiquitination or stability. Consistent with this, siRNA depletion of CSK increased GAB2 and PTPN11 phosphorylation (Kazi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).
Literature References
PubMed ID Title Journal Year
23707526 The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling

Vaapil, M, Bracco, E, Agarwal, S, Kazi, JU, Påhlman, S, Rönnstrand, L

Cell Signal 2013
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Orthologous Events
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Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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