The COOH-terminal SRC kinase (CSK) interacts with FLT3 in a phosphorylation-dependent manner through the SH2 domain of CSK. Interaction with CSK downregulates FLT3-dependent signaling through the AKT and MAP kinase pathway without affecting receptor ubiquitination or stability. Consistent with this, siRNA depletion of CSK increased GAB2 and PTPN11 phosphorylation (Kazi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Vaapil, M, Agarwal, S, Bracco, E, Påhlman, S, Rönnstrand, L
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