Reactome | Active FLT3 binds to ABL2

Active FLT3 binds to ABL2

Stable Identifier

R-HSA-9706287

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The Abelson (ABL) family of non-receptor tyrosine kinase 2 (ABL2, also known as ARG) binds to tyrosine phosphorylated FLT3. ABL2 binding inhibits FLT3-dependent AKT signaling without affecting other downstream pathways like the MAP kinase and STAT cascades, and without affecting FLT3 phosphorylation or stability. The mechanism for ABL2-mediated negative regulation of FLT3 AKT signaling remains to be elucidated (Kazi et al, 2017; reviewed in Kazi and Ronnstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
28086240	ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling Kazi, JU, Rupar, K, Marhäll, A, Moharram, SA, Khanum, F, Shah, K, Gazi, M, Nagaraj, SR, Sun, J, Chougule, RA, Rönnstrand, L	Oncotarget	2017