The Abelson (ABL) family of non-receptor tyrosine kinase 2 (ABL2, also known as ARG) binds to tyrosine phosphorylated FLT3. ABL2 binding inhibits FLT3-dependent AKT signaling without affecting other downstream pathways like the MAP kinase and STAT cascades, and without affecting FLT3 phosphorylation or stability. The mechanism for ABL2-mediated negative regulation of FLT3 AKT signaling remains to be elucidated (Kazi et al, 2017; reviewed in Kazi and Ronnstrand, 2019).
Kazi, JU, Rupar, K, Marhäll, A, Moharram, SA, Khanum, F, Shah, K, Gazi, M, Nagaraj, SR, Sun, J, Chougule, RA, Rönnstrand, L
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