Reactome | MCM7 [nucleoplasm]

MCM7 [nucleoplasm]

Stable Identifier

R-DDI-68555

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

MCM7, Q54RU0

Locations in the PathwayBrowser

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Cell Cycle (Dictyostelium discoideum)

- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - Mitotic G1 phase and G1/S transition (Dictyostelium discoideum)
    - G1/S Transition (Dictyostelium discoideum)
      - Activation of the pre-replicative complex (Dictyostelium discoideum)
        
        Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
  - S Phase (Dictyostelium discoideum)
    - Synthesis of DNA (Dictyostelium discoideum)
      - Switching of origins to a post-replicative state (Dictyostelium discoideum)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)

DNA Replication (Dictyostelium discoideum)

- DNA Replication Pre-Initiation (Dictyostelium discoideum)
  - Activation of the pre-replicative complex (Dictyostelium discoideum)
    - Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
    - DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
    - DNA polymerase epsilon binds at the origin (Dictyostelium discoideum)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Dictyostelium discoideum)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        active pre-replicative complex [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
  - Assembly of the pre-replicative complex (Dictyostelium discoideum)
    - Formation of MCM2-7 complex (Dictyostelium discoideum)
      - MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
    - MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
    - MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
      - MCM7 [nucleoplasm] (Dictyostelium discoideum)
- Synthesis of DNA (Dictyostelium discoideum)
  - Switching of origins to a post-replicative state (Dictyostelium discoideum)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Dictyostelium discoideum)
      - MCM2-7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)
      - MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)
        
        MCM7 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54RU0

Gene Names

MCM7

Reference Genes

BioGPS Gene:8623831 MCM7

dictyBase:DDB_G0282933

ENSEMBL:DDB_G0282933

KEGG Gene (Dictyostelium discoideum):DDB_G0282933 MCM7

Monarch:8623831 MCM7

NCBI Gene:8623831 MCM7

Reference Transcript

RefSeq:XM_634169.1 MCM7

Participates

as an input of

MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)

as a component of

MCM4:MCM6:MCM7 [nucleoplasm] (Dictyostelium discoideum)

Inferred From

MCM7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_639261.1

OpenTargets

ENSG00000166508

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