Reactome | KDM4A [nucleoplasm]

KDM4A [nucleoplasm]

Stable Identifier

R-HSA-351646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JMJD2A, JmjC domain-containing histone demethylation protein 3A, JHD3A_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates HERC2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - KDM4A,B bind H4K20Me2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF168 binds DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75164 KDM4A

Gene Names

KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677

Chain

initiator methionine:1, chain:2-1064

Reference Genes

BioGPS Gene:9682 KDM4A

COSMIC (genes):KDM4A KDM4A

CTD Gene:9682 KDM4A

dbSNP Gene:9682 KDM4A

ENSEMBL:ENSG00000066135 KDM4A

HGNC:22978 KDM4A

KEGG Gene (Homo sapiens):9682 KDM4A

Monarch:9682 KDM4A

NCBI Gene:9682 KDM4A

OMIM:609764 KDM4A

UCSC:O75164 KDM4A

Reference Transcript

Other Identifiers

0006860056

11726729_at

11726730_a_at

16663665

203204_s_at

203205_at

2333430

2333431

2333432

2333433

2333434

2333436

2333439

2333442

2333445

2333448

2333449

2333451

2333452

2333453

2333454

2333457

2333458

2333460

2333461

2333462

2333463

2333464

2333465

2333471

2333472

2333473

2333474

2333475

2333476

2333477

2333478

2GF7

2GFA

2GP3

2GP5

2OQ6

2OQ7

2OS2

2OT7

2OX0

2P5B

2PXJ

2Q8C

2Q8D

2Q8E

2QQR

2QQS

2VD7

2WWJ

2YBK

2YBP

2YBS

32073_at

3NJY

3PDQ

3RVH

3U4S

4AI9

4BIS

4GD4

4URA

4V2V

4V2W

5A7N

5A7O

5A7P

5A7Q

5A7S

5A7W

5A80

5ANQ

5D6W

5D6X

5D6Y

5F2S

5F2W

5F32

5F37

5F39

5F3C

5F3E

5F3G

5F3I

5F5I

5FPV

5FWE

5FY8

5FYC

5FYH

5FYI

5LY1

5LY2

5TVR

5TVS

5VAR

5VGI

5VMP

6CG1

6CG2

6G5W

6G5X

6H8P

7610

7900833

9682

A0A2R8YDF7

A_14_P132839

A_23_P74446

A_33_P3420655

AAH02558

AB014577

AC092815

AL451062

BAA31652

BC002558

CCDS491

ENSG00000066135

ENSP00000361473

ENST00000372396

ENST00000372396.3

EntrezGene:9682

EntrezGene:KDM4A

g12803466_3p_a_at

g7662245_3p_at

GE53384

GO:0001650

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006464

GO:0006914

GO:0008150

GO:0008270

GO:0009056

GO:0009058

GO:0010507

GO:0010629

GO:0016032

GO:0016491

GO:0016577

GO:0019899

GO:0031625

GO:0032452

GO:0032454

GO:0032991

GO:0033169

GO:0034641

GO:0035064

GO:0035097

GO:0042393

GO:0043167

GO:0043226

GO:0044403

GO:0045892

GO:0046872

GO:0051213

GO:0051276

GO:0051864

GO:0055114

GO:0070544

HGNC:22978

HPA007610

ILMN_1690218

ILMN_1736650

IPR001965

IPR002999

IPR003347

IPR003349

IPR011011

IPR013083

IPR034732

IPR040477

KDM4A

KDM4A-201

MIM:609764

NM_014663

NP_055478

PF02373

PF02375

PF13831

PF13832

PF18104

PH_hs_0009402

SM00249

SM00333

SM00545

SM00558

TC01000549.hg

UPI000013D35A

XM_005271354

XM_005271355

XP_005271411

XP_005271412

Z70219_at

Participant Of

hasMember

Other forms of this molecule

K48PolyUb-KDM4A [nucleoplasm]

Inferred To

Kdm4a [nucleoplasm] (Mus musculus)

Kdm4a [nucleoplasm] (Rattus norvegicus)

jmjd-2 [nucleoplasm] (Caenorhabditis elegans)

jmj3 [nucleoplasm] (Schizosaccharomyces pombe)

kdm4a [nucleoplasm] (Xenopus tropicalis)

Kdm4B [nucleoplasm] (Drosophila melanogaster)

Homologues of KDM4A [nucleoplasm] (Gallus gallus)

KDM4A [nucleoplasm] (Bos taurus)

KDM4A [nucleoplasm] (Canis familiaris)

KDM4A [nucleoplasm] (Gallus gallus)

KDM4A [nucleoplasm] (Sus scrofa)

kdm4ab [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_005271412.1, XP_005271411.1, NP_055478.2

OpenTargets

ENSG00000066135

ZINC - Substances

KDM4A_HUMAN

HPA

ENSG00000066135-KDM4A

GeneCards

O75164

ZINC target

O75164

Ensembl

ENSG00000066135, ENSP00000361473, ENST00000372396

PRO

O75164

ZINC - Predictions - Purchasable

KDM4A_HUMAN

PDB

5F5I, 6H4O, 3RVH, 3NJY, 4V2V, 4URA, 5LY1, 5FYH, 4V2W, 5D6W, 2YBK, 4BIS, 5FYI, 6H4Y, 6H8P, 5LY2, 6H4S, 6H4X, 6H4R, 5TVS, 5F3C, 6H4U, 6HGT, 5F3E, 6H4T, 6G5W, 5FPV, 5A7W, 5VGI, 5TVR, 5A80, 2GP3, 5FY8, 2OQ7, 5VAR, 6H4W, 2P5B, 5FYC, 2GP5, 6H4V, 6G5X, 3U4S, 5A7Q, 5F37, 2PXJ, 5F2W, 2QQR, 5F3I, 5A7P, 2WWJ, 5A7S, 2OX0, 3PDQ, 2QQS, 5F39, 2OT7, 6H4Q, 2GF7, 2OQ6, 2YBP, 2Q8C, 6CG2, 6H4P, 5D6Y, 5D6X, 2YBS, 5VMP, 2VD7, 6CG1, 2Q8D, 5A7N, 4GD4, 2OS2, 2Q8E, 5F3G, 2GFA, 5F32, 5FWE, 4AI9, 5A7O, 5ANQ, 5F2S

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.743	7
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.462	3

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