Reactome | KDM4A [nucleoplasm]

KDM4A [nucleoplasm]

Stable Identifier

R-HSA-351646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JMJD2A, JmjC domain-containing histone demethylation protein 3A, JHD3A_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates HERC2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - KDM4A,B bind H4K20Me2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF168 binds DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75164 KDM4A

Gene Names

KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677

Chain

initiator methionine:1, chain:2-1064

Reference Genes

BioGPS Gene:9682 KDM4A

COSMIC (genes):KDM4A KDM4A

CTD Gene:9682 KDM4A

dbSNP Gene:9682 KDM4A

ENSEMBL:ENSG00000066135 KDM4A

HGNC:22978 KDM4A

KEGG Gene (Homo sapiens):9682 KDM4A

Monarch:9682 KDM4A

NCBI Gene:9682 KDM4A

OMIM:609764 KDM4A

UCSC:O75164 KDM4A

Reference Transcript

Other Identifiers

0006860056

11726729_at

11726730_a_at

16663665

203204_PM_s_at

203204_s_at

203205_PM_at

203205_at

2333430

2333431

2333432

2333433

2333434

2333436

2333439

2333442

2333445

2333448

2333449

2333451

2333452

2333453

2333454

2333457

2333458

2333460

2333461

2333462

2333463

2333464

2333465

2333471

2333472

2333473

2333474

2333475

2333476

2333477

2333478

32073_at

7900833

9682

A_14_P132839

A_23_P74446

A_33_P3420655

GE53384

GO:0001650

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005730

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006464

GO:0006914

GO:0006950

GO:0008150

GO:0008219

GO:0008270

GO:0009056

GO:0009058

GO:0010507

GO:0010628

GO:0010629

GO:0014898

GO:0016491

GO:0016577

GO:0019899

GO:0030154

GO:0031625

GO:0031667

GO:0032452

GO:0032454

GO:0033169

GO:0034641

GO:0035064

GO:0042393

GO:0043167

GO:0043226

GO:0045666

GO:0045892

GO:0046872

GO:0048712

GO:0048856

GO:0051213

GO:0051276

GO:0051864

GO:0060548

GO:0070544

GO:0140681

GO:0140684

GO:1900113

HMNXSV003046382

ILMN_1690218

ILMN_1736650

PH_hs_0009402

TC01000549.hg

Z70219_at

g12803466_3p_a_at

g7662245_3p_at

Participates

as a member of

Other forms of this molecule

K48PolyUb-KDM4A [nucleoplasm]

Inferred To

Kdm4a [nucleoplasm] (Mus musculus)

Kdm4a [nucleoplasm] (Rattus norvegicus)

jmjd-2 [nucleoplasm] (Caenorhabditis elegans)

kdm4a [nucleoplasm] (Xenopus tropicalis)

KDM4A [nucleoplasm] (Bos taurus)

KDM4A [nucleoplasm] (Canis familiaris)

KDM4A [nucleoplasm] (Gallus gallus)

KDM4A [nucleoplasm] (Sus scrofa)

kdm4ab [nucleoplasm] (Danio rerio)

Cross References

RefSeq

XP_005271411.1, NP_055478.2, XP_005271412.1

Guide to Pharmacology - Targets

2675

OpenTargets

ENSG00000066135

ZINC - Substances

KDM4A_HUMAN

GeneCards

O75164

HPA

ENSG00000066135-KDM4A

ZINC target

O75164

Ensembl

ENSG00000066135, ENSP00000361473, ENST00000372396

PRO

O75164

Pharos - Targets

O75164

ZINC - Predictions - Purchasable

KDM4A_HUMAN

PDB

5VMP, 4URA, 5A80, 5FPV, 3PDQ, 4V2W, 2PXJ, 6HGT, 5D6X, 6CG2, 5D6Y, 2GP5, 6H4S, 2VD7, 5FY8, 5F2S, 2Q8E, 2OS2, 2GP3, 7D4A, 6H4T, 5F32, 2Q8D, 2OQ7, 2GF7, 5A7S, 2YBS, 5A7N, 5F3G, 4GD4, 2YBP, 5F2W, 2Q8C, 6H4V, 6H4W, 5A7O, 5F39, 2QQS, 5A7P, 3RVH, 2YBK, 5F37, 6H4Q, 2QQR, 6H4X, 6H4P, 6H8P, 6H4Y, 6G5W, 6CG1, 2GFA, 5A7Q, 5F3C, 6H4R, 5ANQ, 4BIS, 5FWE, 5F3E, 2P5B, 5FYC, 6H4U, 6G5X, 5TVR, 2OQ6, 5F5I, 5F3I, 3U4S, 5VAR, 5FYH, 5LY1, 5TVS, 4AI9, 2WWJ, 2OT7, 2OX0, 5VGI, 5FYI, 5A7W, 6H4O, 4V2V, 5D6W, 5LY2, 3NJY

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	HIST1H4A [extracellular region] (R-HSA-977569) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.743	7
UniProt:Q16695 H3-4	3	HIST3H3 [nucleoplasm] (R-HSA-181914) Me3K5-HIST3H3 [nucleoplasm] (R-HSA-2245188) Me2K5-HIST3H3 [nucleoplasm] (R-HSA-2245186)	0.618	6
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.462	3
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.462	3

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