Reactome | KDM4A [nucleoplasm]

KDM4A

Stable Identifier

R-HSA-351646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JMJD2A, JmjC domain-containing histone demethylation protein 3A, JHD3A_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates HERC2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 and PIAS4 are recruited to DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - KDM4A,B bind H4K20Me2 (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF168 binds DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Homo sapiens)
        
        KDM4A,B [nucleoplasm] (Homo sapiens)
        
        KDM4A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75164 KDM4A

Gene Names

KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677

Chain

initiator methionine:1, chain:2-1064

Reference Genes

BioGPS Gene:9682 KDM4A

COSMIC (genes):KDM4A KDM4A

CTD Gene:9682 KDM4A

dbSNP Gene:9682 KDM4A

ENSEMBL:ENSG00000066135 KDM4A

HGNC:22978 KDM4A

KEGG Gene (Homo sapiens):hsa:9682 KDM4A

Monarch:9682 KDM4A

NCBI Gene:9682 KDM4A

OMIM:609764 KDM4A

UCSC:O75164 KDM4A

Reference Transcript

Other Identifiers

0006860056

11726729_at

11726730_a_at

16663665

203204_s_at

203205_at

2GF7

2GFA

2GP3

2GP5

2OQ6

2OQ7

2OS2

2OT7

2OX0

2P5B

2PXJ

2Q8C

2Q8D

2Q8E

2QQR

2QQS

2VD7

2WWJ

2YBK

2YBP

2YBS

32073_at

3NJY

3PDQ

3RVH

3U4S

4AI9

4BIS

4GD4

4URA

4V2V

4V2W

5A7N

5A7O

5A7P

5A7Q

5A7S

5A7W

5A80

5ANQ

5D6W

5D6X

5D6Y

5F2S

5F2W

5F32

5F37

5F39

5F3C

5F3E

5F3G

5F3I

5F5I

5FPV

5FWE

5FY8

5FYC

5FYH

5FYI

5LY1

5LY2

5TVR

5TVS

7610

7900833

9682

A_14_P132839

A_23_P74446

CCDS491

ENSG00000066135

ENSP00000361473

ENST00000372396

EntrezGene:9682

g12803466_3p_a_at

g7662245_3p_at

GE53384

GO:0001650

GO:0005515

GO:0005634

GO:0005654

GO:0005721

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0008270

GO:0010507

GO:0010628

GO:0010629

GO:0014898

GO:0016032

GO:0016491

GO:0016569

GO:0016577

GO:0031625

GO:0031667

GO:0032452

GO:0032454

GO:0033169

GO:0035064

GO:0045666

GO:0045892

GO:0046872

GO:0048712

GO:0051213

GO:0051864

GO:0055114

GO:0060548

GO:0070544

GO:1900113

HGNC:22978

HPA007610

Hs.155983

ILMN_1690218

ILMN_1736650

KDM4A

KDM4A-201

MIM:609764

NM_014663

NP_055478

PF02373

PF02375

PF13831

PF13832

PH_hs_0009402

SM00249

SM00333

SM00545

SM00558

TC01000549.hg

uc001cjx.4

UPI000013D35A

XM_005271354

XM_005271355

XM_005271356

XM_017002912

XP_005271411

XP_005271412

XP_005271413

XP_016858401

Z70219_at

Participant Of

hasMember

Other forms of this molecule

K48PolyUb-KDM4A [nucleoplasm]

Inferred To

Homologues of KDM4A [nucleoplasm] (Arabidopsis thaliana)

Homologues of KDM4A [nucleoplasm] (Danio rerio)

Homologues of KDM4A [nucleoplasm] (Drosophila melanogaster)

Homologues of KDM4A [nucleoplasm] (Gallus gallus)

Homologues of KDM4A [nucleoplasm] (Oryza sativa)

Homologues of KDM4A [nucleoplasm] (Rattus norvegicus)

Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of KDM4A [nucleoplasm] (Sus scrofa)

KDM4A [nucleoplasm] (Arabidopsis thaliana)

KDM4A [nucleoplasm] (Bos taurus)

KDM4A [nucleoplasm] (Caenorhabditis elegans)

KDM4A [nucleoplasm] (Canis familiaris)

KDM4A [nucleoplasm] (Danio rerio)

KDM4A [nucleoplasm] (Drosophila melanogaster)

KDM4A [nucleoplasm] (Gallus gallus)

KDM4A [nucleoplasm] (Mus musculus)

KDM4A [nucleoplasm] (Oryza sativa)

KDM4A [nucleoplasm] (Plasmodium falciparum)

KDM4A [nucleoplasm] (Rattus norvegicus)

KDM4A [nucleoplasm] (Saccharomyces cerevisiae)

KDM4A [nucleoplasm] (Sus scrofa)

KDM4A [nucleoplasm] (Taeniopygia guttata)

KDM4A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_055478.2, XP_005271411.1, XP_005271412.1

Brenda

1.14.11.B2, 1.14.11.27, 1.14.11.B1

ZINC - Substances

KDM4A_HUMAN

GeneCards

O75164

DOCK Blaster

5F2S, 2GF7, 2GFA, 5LY2, 5F37, 2YBS, 5F39, 5F2W, 2YBK, 2YBP, 2OX0, 5F3C, 5F3E, 5LY1, 5F32, 2WWJ, 5FPV, 2P5B, 3U4S, 2VD7, 2OT7, 5TVS, 5TVR, 5ANQ, 5A7S, 5A7W, 5A7N, 5A7P, 5A7O, 5A80, 2QQR, 3NJY, 2QQS, 5A7Q, 5D6W, 5D6Y, 2OS2, 2OQ6, 2OQ7, 4V2W, 2PXJ, 5FYI, 5FYH, 2Q8C, 2Q8D, 2Q8E, 5FWE, 3RVH, 3PDQ, 4BIS, 2GP5, 2GP3, 5F3I, 5F3G, 4V2V, 4URA, 5F5I, 4AI9, 5FY8, 5FYC, 4GD4, 5D6X

ZINC target

O75164

PRO

O75164

ZINC - Predictions - Purchasable

KDM4A_HUMAN

PDB

2YBP, 5F3G, 2YBS, 3NJY, 3PDQ, 5F3I, 3RVH, 5F5I, 3U4S, 5F39, 2Q8D, 2Q8E, 5F3C, 2QQR, 2QQS, 2VD7, 2WWJ, 2YBK, 5F3E, 2OT7, 5F32, 2OX0, 2P5B, 5F37, 2PXJ, 2Q8C, 2GFA, 5VGI, 5D6Y, 2GP3, 2GP5, 5VMP, 5F2S, 2OQ6, 2OQ7, 5F2W, 2OS2, 5ANQ, 5TVR, 5D6W, 5TVS, 5D6X, 2GF7, 5A7Q, 5FYI, 5A7S, 5A7W, 5LY1, 5A80, 4V2W, 4V2V, 4URA, 5FWE, 4GD4, 5FPV, 4BIS, 4AI9, 5A7P, 5FYH, 5A7O, 5FYC, 5A7N, 5FY8, 5LY2

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 HIST1H4A	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.743	7
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.462	3