Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
2xHC-Myri-INS(25-53) [extracellular region]
Stable Identifier
R-HSA-429343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin_Detemir B Chain
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Amyloid fibrils have additional components (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Human insulin analogue amyloid fibrils [extracellular region] (Homo sapiens)
Human Insulin Analogues [extracellular region] (Homo sapiens)
Insulin_Detemir(Levemir) [extracellular region] (Homo sapiens)
2xHC-Myri-INS(25-53) [extracellular region] (Homo sapiens)
Amyloid fibrils [plasma membrane] (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Human insulin analogue amyloid fibrils [extracellular region] (Homo sapiens)
Human Insulin Analogues [extracellular region] (Homo sapiens)
Insulin_Detemir(Levemir) [extracellular region] (Homo sapiens)
2xHC-Myri-INS(25-53) [extracellular region] (Homo sapiens)
Amyloid precursor proteins form ordered fibrils (Homo sapiens)
Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
Human insulin analogue amyloid fibrils [extracellular region] (Homo sapiens)
Human Insulin Analogues [extracellular region] (Homo sapiens)
Insulin_Detemir(Levemir) [extracellular region] (Homo sapiens)
2xHC-Myri-INS(25-53) [extracellular region] (Homo sapiens)
Amyloid fibril monomers [extracellular region] (Homo sapiens)
Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
Human Insulin Analogues [extracellular region] (Homo sapiens)
Insulin_Detemir(Levemir) [extracellular region] (Homo sapiens)
2xHC-Myri-INS(25-53) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
COSMIC (genes):INS INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
Participates
as a component of
Insulin_Detemir(Levemir) [extracellular region] (Homo sapiens)
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
2xHC-INS(25-54) [extracellular region]
4xHC-INS(90-110) [extracellular region]
INS(25-54) [endosome lumen]
INS(90-110) [endosome lumen]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [Golgi membrane]
Modified Residues
Name
N6-myristoyl-L-lysine at 53
Coordinate
53
PsiMod Name
N6-myristoyl-L-lysine [MOD:00087]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 31 and 96
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 43 and 109
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01308 INS
20
6xHC-INS(25-110) [Golgi lumen]
(R-HSA-264890)
6xHC-INS(25-110) [secretory granule lumen]
(R-HSA-264984)
2xHC-INS(25-56) [secretory granule lumen]
(R-HSA-9023201)
INS(57-89) [secretory granule lumen]
(R-HSA-9023172)
4xHC-INS(57-110) [secretory granule lumen]
(R-HSA-9023174)
6xHC-INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-265075)
INS(57-87) [extracellular region]
(R-HSA-265157)
C Peptide [secretory granule lumen]
(R-HSA-265011)
4xHC-INS(90-110) [secretory granule lumen]
(R-HSA-264971)
2xHC-INS(25-54) [secretory granule lumen]
(R-HSA-264902)
INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-264893)
Insulin Aspart B Chain [extracellular region]
(R-HSA-429393)
Insulin Humalog B Chain [extracellular region]
(R-HSA-429397)
Insulin Glulisine B Chain [extracellular region]
(R-HSA-429465)
2xHC-Myri-INS(25-53) [extracellular region]
(R-HSA-429343)
Insulin Glargine A Chain [extracellular region]
(R-HSA-429369)
Insulin Glargine B Chain [extracellular region]
(R-HSA-429347)
2xHC-INS(25-54) [extracellular region]
(R-HSA-74673)
4xHC-INS(90-110) [extracellular region]
(R-HSA-74672)
INS(25-54) [endosome lumen]
(R-HSA-141723)
0.971
21
UniProt:P06213-2 INSR
0.697
6
UniProt:P14735-1 IDE
0.618
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text