6xHC-INS(25-110) [Golgi membrane]

Stable Identifier
R-HSA-6808710
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Proinsulin (cystine bonded)
Icon
6xHC-INS(25-110) [Golgi membrane] icon
6xHC-INS(25-110) [Golgi membrane] icon
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
COSMIC (genes):INS INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
Participates
as a member of
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
2xHC-INS(25-54) [extracellular region]
4xHC-INS(90-110) [extracellular region]
INS(25-54) [endosome lumen]
INS(90-110) [endosome lumen]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
Inferred To
INS [Golgi membrane] (Bos taurus)
INS [Golgi membrane] (Canis familiaris)
INS [Golgi membrane] (Gallus gallus)
INS [Golgi membrane] (Sus scrofa)
Ins1 [Golgi membrane] (Mus musculus)
Ins1 [Golgi membrane] (Rattus norvegicus)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 31 and 96
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 43 and 109
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100
Coordinate
95
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  20 0.971 21
 UniProt:P06213-2 INSR      0.697 6
 UniProt:P14735-1 IDE      0.618 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:Q8IUG1 KRTAP1-3  1 0.556 3
 UniProt:Q07627 KRTAP1-1  1 0.556 3
 UniProt:A8MQ03 CRTP1      0.556 3
 UniProt:P0DPK4 NOTCH2NLC  1 0.556 3
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