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SLC7A11 [plasma membrane]
Stable Identifier
R-HSA-378515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cystine/glutamate transporter
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)
SLC7A11 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Basigin interactions (Homo sapiens)
Basigin binds CD98 complex (Homo sapiens)
Basigin:CD98hc complex [plasma membrane] (Homo sapiens)
CD98hc complex [plasma membrane] (Homo sapiens)
SLC7A11:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
SLC7A11 [plasma membrane] (Homo sapiens)
CD98hc complex [plasma membrane] (Homo sapiens)
SLC7A11:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
SLC7A11 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)
SLC7A11:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
SLC7A11 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPY5 SLC7A11
Gene Names
SLC7A11
Chain
chain:1-501
Reference Genes
BioGPS Gene:23657 SLC7A11
COSMIC (genes):SLC7A11 SLC7A11
CTD Gene:23657 SLC7A11
dbSNP Gene:23657 SLC7A11
ENSEMBL:ENSG00000151012 SLC7A11
ENSEMBL:ENSG00000151012.13 SLC7A11
HGNC:11059 SLC7A11
KEGG Gene (Homo sapiens):23657 SLC7A11
Monarch:23657 SLC7A11
NCBI Gene:23657 SLC7A11
OMIM:607933 SLC7A11
UCSC:Q9UPY5 SLC7A11
Reference Transcript
RefSeq:NM_014331.3 SLC7A11
Other Identifiers
11721875_at
11721876_s_at
11744680_a_at
16979917
207528_PM_s_at
207528_s_at
209921_PM_at
209921_at
217678_3p_at
217678_PM_at
217678_at
23657
2786325
2786326
2786327
2786328
2786329
2786330
2786331
2786335
2786337
2786339
2786340
2786341
2786348
2786351
2786352
2786354
2786356
2786360
2786361
34131_at
54049_at
8102800
A_24_P200420
A_32_P165477
A_32_P42684
A_33_P3242623
GE80238
GO:0002376
GO:0003333
GO:0005215
GO:0005515
GO:0005886
GO:0006520
GO:0006575
GO:0006749
GO:0006790
GO:0006865
GO:0006979
GO:0007155
GO:0007420
GO:0008542
GO:0009636
GO:0009986
GO:0012501
GO:0014070
GO:0015179
GO:0015327
GO:0015804
GO:0015811
GO:0015813
GO:0016020
GO:0021591
GO:0021756
GO:0022857
GO:0023052
GO:0030154
GO:0030534
GO:0031526
GO:0031528
GO:0033029
GO:0034330
GO:0034599
GO:0034775
GO:0035094
GO:0042060
GO:0042127
GO:0042995
GO:0045177
GO:0048021
GO:0048286
GO:0048856
GO:0050804
GO:0050807
GO:0050877
GO:0051223
GO:0051775
GO:0055085
GO:0060173
GO:0061024
GO:0070306
GO:0070527
GO:0071702
GO:0090461
GO:0097449
GO:0098712
GO:0110076
GO:0140206
GO:0140924
GO:0140926
GO:1900407
GO:1901494
GO:1903786
GO:1904717
GO:2000211
HMNXSV003005220
Hs.284235.0.S1_3p_x_at
ILMN_1655229
PH_hs_0027559
TC04001570.hg
g13516845_3p_at
g7657682_3p_a_at
Participates
as an output of
AcK-NFE2L2-dependent SLC7A11 expression (Homo sapiens)
as a component of
SLC7A11:SLC3A2 heterodimer [plasma membrane] (Homo sapiens)
Inferred To
Dmel\CG1607 [plasma membrane]
(Drosophila melanogaster)
slc7a11 [plasma membrane]
(Xenopus tropicalis)
xCT [plasma membrane]
(Canis familiaris)
gb [plasma membrane]
(Drosophila melanogaster)
SLC7A11 [plasma membrane]
(Bos taurus)
SLC7A11 [plasma membrane]
(Danio rerio)
SLC7A11 [plasma membrane]
(Mus musculus)
SLC7A11 [plasma membrane]
(Sus scrofa)
Homologues of SLC7A11 [plasma membrane]
(Drosophila melanogaster)
mnd [plasma membrane]
(Drosophila melanogaster)
JhI-21 [plasma membrane]
(Drosophila melanogaster)
Slc7a11 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_055146.1
Guide to Pharmacology - Targets
902
OpenTargets
ENSG00000151012
ZINC - Substances
XCT_HUMAN
ZINC - Biogenic
XCT_HUMAN
ZINC target
Q9UPY5
PRO
Q9UPY5
PDB
7P9V
,
7CCS
,
7P9U
,
7EPZ
ZINC - Metabolites
XCT_HUMAN
HPA
ENSG00000151012-SLC7A11
GeneCards
Q9UPY5
Ensembl
ENST00000280612
,
ENSG00000151012
,
ENSP00000280612
Pharos - Targets
Q9UPY5
ZINC - Predictions - Purchasable
XCT_HUMAN
HMDB Protein
HMDBP02956
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:P08195-4 SLC3A2
0.556
3
UniProt:P16070 CD44
2
CD44 [secretory granule membrane]
(R-HSA-6804776)
CD44 [plasma membrane]
(R-HSA-1031688)
0.537
4
UniProt:Q8N4P2 IFT70B
2
TTC30B [ciliary tip]
(R-HSA-5637970)
TTC30B [cilium]
(R-HSA-5637971)
0.508
2
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