Insulin Glargine B Chain [extracellular region]

Stable Identifier
R-HSA-429347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Icon
Insulin Glargine B Chain [extracellular region] icon
Insulin Glargine B Chain [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
BioGPS Gene:3630 INS
COSMIC (genes):INS INS
CTD Gene:3630 INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
ENSEMBL_homo_sapiens_GENE:ENSG00000254647 INS
HGNC:6081 INS
KEGG Gene (Homo sapiens):3630 INS
Monarch:3630 INS
NCBI Gene:3630 INS
OMIM:176730 INS
UCSC:P01308 INS
Reference Transcript
Other Identifiers
11741851_s_at
12098
160038_s_at
1A7F
1AI0
1AIY
1B9E
1BEN
1EFE
1EV3
1EV6
1EVR
1FU2
1FUB
1G7A
1G7B
1GUJ
1HIQ
1HIS
1HIT
1HLS
1HTV
1HUI
1IOG
1IOH
1J73
1JCA
1JCO
1JK8
1K3M
1KMF
1LKQ
1LPH
1MHI
1MHJ
1MSO
1OS3
1OS4
1Q4V
1QIY
1QIZ
1QJ0
1RWE
1SF1
1SJT
1SJU
1T0C
1T1K
1T1P
1T1Q
1TRZ
1TYL
1TYM
1UZ9
1VKT
1W8P
1XDA
1XGL
1XW7
1ZEG
1ZEH
1ZNJ
206598_at
2AIY
2C8Q
2C8R
2CEU
2G54
2G56
2H67
2HH4
2HHO
2HIU
2JMN
2JUM
2JUU
2JUV
2JV1
2JZQ
2K91
2K9R
2KJJ
2KJU
2KQP
2KQQ
2KXK
2L1Y
2L1Z
2LGB
2LWZ
2M1D
2M1E
2M2M
2M2N
2M2O
2M2P
2MLI
2MPG
2MPI
2MVC
2MVD
2N2V
2N2W
2N2X
2OLY
2OLZ
2OM0
2OM1
2OMG
2OMH
2OMI
2OMQ
2QIU
2R34
2R35
2R36
2RN5
2VJZ
2VK0
2W44
2WBY
2WC0
2WRU
2WRV
2WRW
2WRX
2WS0
2WS1
2WS4
2WS6
2WS7
3359172
3359173
3359174
3359176
3359177
3359178
3359179
3630
3AIY
3BXQ
3E7Y
3E7Z
3EXX
3FQ9
3HYD
3I3Z
3I40
3ILG
3INC
3IR0
3JSD
3KQ6
3P2X
3P33
3Q6E
3ROV
3TT8
3U4N
3UTQ
3UTS
3UTT
3V19
3V1G
3W11
3W12
3W13
3W7Y
3W7Z
3W80
3ZI3
3ZQR
3ZS2
3ZU1
48
4932
4AIY
4AJX
4AJZ
4AK0
4AKJ
4CXL
4CXN
4CY7
4EFX
4EWW
4EWX
4EWZ
4EX0
4EX1
4EXX
4EY1
4EY9
4EYD
4EYN
4EYP
4F0N
4F0O
4F1A
4F1B
4F1C
4F1D
4F1F
4F1G
4F4T
4F4V
4F51
4F8F
4FG3
4FKA
4GBC
4GBI
4GBK
4GBL
4GBN
4IUZ
4IYD
4IYF
4NIB
4OGA
4P65
4RXW
4UNE
4UNG
4UNH
4WDI
4XC4
4Y19
4Y1A
4Z76
4Z77
4Z78
53843
5AIY
5BOQ
5BPO
5BQQ
5BTS
5C0D
5CJO
5CNY
5CO2
5CO6
5CO9
5E7W
5EMS
5EN9
5ENA
5HPR
5HPU
5HQI
5HRQ
5HYJ
5MAM
5MHD
5MT3
5MT9
5MWQ
5T7R
5UDP
5UOZ
5UQA
5URT
5URU
5USP
5USS
5USV
5UU2
5UU3
5UU4
5VIZ
5WBT
5WDM
5WOB
6B3Q
6B70
6BFC
6CE7
6CE9
6CEB
6CK2
A6XGL2
A_23_P1981
AAA59172
AAA59173
AAA59179
AAH05255
AAN39451
AAP35454
AAW83741
AFK93533
AJ009655
AY138590
AY899304
BC005255
BT006808
C9JNR5
CAA08766
CAA23828
CAA49913
CAB000048
CAB012098
CAB053843
CCDS7729
CH471158
EAX02488
EAX02489
ENSG00000254647
ENSP00000250971
ENSP00000370731
ENSP00000380432
ENST00000250971
ENST00000250971.7
ENST00000381330
ENST00000381330.4
ENST00000397262
ENST00000397262.5
EntrezGene:3630
g4557670_3p_at
GE59971
GO:0000139
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0003674
GO:0005158
GO:0005159
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0005975
GO:0006006
GO:0006355
GO:0006521
GO:0006810
GO:0006888
GO:0006950
GO:0006953
GO:0007165
GO:0007186
GO:0007267
GO:0008150
GO:0008284
GO:0008286
GO:0010469
GO:0010628
GO:0010750
GO:0014068
GO:0016192
GO:0019899
GO:0022898
GO:0030133
GO:0030307
GO:0030335
GO:0031410
GO:0031904
GO:0031954
GO:0032148
GO:0032270
GO:0032460
GO:0032880
GO:0033116
GO:0033861
GO:0034774
GO:0042060
GO:0042177
GO:0042592
GO:0042593
GO:0042802
GO:0043226
GO:0043410
GO:0044267
GO:0044281
GO:0045597
GO:0045721
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0046889
GO:0048167
GO:0050708
GO:0050709
GO:0050715
GO:0050877
GO:0050890
GO:0050995
GO:0051000
GO:0051092
GO:0051897
GO:0055089
GO:0060266
GO:0060267
GO:0090277
GO:0090336
GO:0097755
GO:0097756
GO:1900182
GO:1900273
GO:1902176
GO:1902952
GO:1903076
GO:1903427
GO:1990535
GO:2000252
HGNC:6081
HPA004932
I3WAC9
ILMN_1666966
INS
INS-201
INS-202
INS-203
IPR004825
IPR016179
IPR022352
IPR022353
IPR036438
J00265
J00268_s_at
JQ951950
L15440
M10039
MIM:125852
MIM:176730
MIM:606176
MIM:613370
MIM:616214
NM_000207
NM_001185097
NM_001185098
NM_001291897
NP_000198
NP_001172026
NP_001172027
NP_001278826
PF00049
PH_hs_0005022
PH_hs_0031401
PR00276
PR00277
SM00078
UPI00000017EA
V00565
V00565_s_at
X70508
Participant Of
hasComponent
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
INS(57-87) [extracellular region]
INS(57-87) [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
6xHC-INS(25-110) [Golgi membrane]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
INS(90-110) [endosome lumen]
INS(25-54) [endosome lumen]
4xHC-INS(90-110) [extracellular region]
2xHC-INS(25-54) [extracellular region]
Modified Residues
Name
Intra-chain Crosslink via half cystine at 31 and 96
Coordinate
31
PsiMod Name
half cystine [MOD:00798]
PsiMod Definition
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.
Name
Intra-chain Crosslink via half cystine at 43 and 109
Coordinate
43
PsiMod Name
half cystine [MOD:00798]
PsiMod Definition
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.
Name
Replacement of residues 54 to 54 by TRR
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Orphanet
PDB
1XW7, 5BQQ, 1Q4V, 5UQA, 1VKT, 2HIU, 5HYJ, 5USV, 4GBK, 5UDP, 1LKQ, 2OMQ, 3I3Z, 4IYF, 2WRV, 4Y1A, 4F1G, 1SJT, 4GBI, 5MAM, 2HHO, 4Y19, 1SJU, 5HPU, 4EWX, 4CY7, 4F8F, 1ZEH, 2WRW, 1T1Q, 5UOZ, 4EWW, 5HPR, 1HUI, 1MHI, 2MLI, 4XC4, 6CE7, 2LWZ, 3ROV, 6B70, 2K9R, 1XGL, 4EY9, 5ENA, 2KQP, 1OS3, 4AKJ, 1TYM, 5MWQ, 1OS4, 2KQQ, 2OLY, 4EY1, 1JK8, 5EN9, 5VIZ, 4FG3, 1MSO, 1T1P, 4F0N, 4GBN, 5WBT, 2R35, 3IR0, 5BTS, 2JMN, 4GBL, 3KQ6, 1A7F, 5HQI, 4EWZ, 3BXQ, 1GUJ, 4P65, 5E7W, 3I40, 2WS0, 4F4T, 2WRX, 2R34, 3ZS2, 6CEB, 4AIY, 4EX0, 2KJU, 5AIY, 4EYN, 3E7Z, 5C0D, 3P33, 1JCO, 6CE9, 1TRZ, 4EYD, 1KMF, 3ZQR, 3TT8, 2RN5, 3U4N, 1MHJ, 4F1A, 4F0O, 2OM0, 2MVD, 3INC, 2OLZ, 2M2O, 2MVC, 2L1Y, 1G7A, 2N2V, 2M2N, 2JUU, 3P2X, 1J73, 6BFC, 2KJJ, 2JUV, 1HLS, 3E7Y, 1G7B, 4WDI, 5UU2, 1JCA, 2N2W, 4AJX, 1T0C, 1AI0, 2W44, 3W11, 2KXK, 2WS4, 2R36, 1BEN, 2C8Q, 4AJZ, 2QIU, 2WS1, 3W7Y, 2H67, 1ZNJ, 3JSD, 3W7Z, 2M1D, 2WBY, 4F51, 4Z77, 4EX1, 2MPI, 4IUZ, 4Z76, 3Q6E, 4F4V, 1LPH, 4F1B, 3UTS, 1HIQ, 1EV3, 4OGA, 1SF1, 3V19, 3EXX, 3UTQ, 4F1C, 4EYP, 4RXW, 2MPG, 5URU, 2OMG, 3AIY, 4NIB, 4UNE, 1IOG, 6HN5, 5URT, 2L1Z, 5UU4, 1EFE, 4FKA, 1K3M, 2G54, 3HYD, 1QIY, 5MT3, 2G56, 5HRQ, 5UU3, 2JV1, 3ZI3, 5CNY, 2OM1, 5CO2, 5T7R, 2N2X, 2M2P, 5WOB, 2VJZ, 5CJO, 2VK0, 1UZ9, 4AK0, 6CK2, 1FUB, 1B9E, 3W13, 1W8P, 2WS7, 2C8R, 3FQ9, 1EVR, 3W80, 2M2M, 2AIY, 3W12, 2JUM, 2WS6, 4Z78, 5USS, 3ILG, 5BPO, 1IOH, 4GBC, 2WRU, 2OMI, 2WC0, 4F1D, 1ZEG, 1FU2, 5USP, 2M1E, 2K91, 6B3Q, 4IYD, 4F1F, 4UNG, 4CXL, 5WDM, 1HIS, 2LGB, 4UNH, 4CXN, 1AIY, 2JZQ, 1HIT, 3V1G, 2HH4, 3UTT, 5BOQ, 4EFX, 2OMH, 1TYL, 1RWE, 5MHD, 5MT9, 5CO9, 2CEU, 1T1K, 4EXX, 1QJ0, 1XDA, 5CO6, 1QIZ, 1HTV, 1EV6, 5EMS, 3ZU1
Interactors (7)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  25 0.968 20
 UniProt:P14735-1 IDE      0.618 3
 IntAct:EBI-11749135 KRTAP13      0.488 2
 UniProt:Q6UY14-3 ADAMTSL4      0.488 2
 UniProt:Q7Z3S9 NT2NA      0.488 2
 UniProt:Q07627 KRTAP1-1  1 0.488 2
 UniProt:A8MQ03 CRTP1      0.488 2