Insulin Glargine B Chain [extracellular region]

Stable Identifier
R-HSA-429347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Icon
Insulin Glargine B Chain [extracellular region] icon
Insulin Glargine B Chain [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
BioGPS Gene:3630 INS
COSMIC (genes):INS INS
CTD Gene:3630 INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
HGNC:6081 INS
KEGG Gene (Homo sapiens):3630 INS
Monarch:3630 INS
NCBI Gene:3630 INS
OMIM:176730 INS
UCSC:P01308 INS
Reference Transcript
Other Identifiers
11741851_s_at
160038_s_at
206598_at
3359172
3359173
3359174
3359176
3359177
3359178
3359179
3630
A_23_P1981
GE59971
GO:0000139
GO:0000278
GO:0001819
GO:0002020
GO:0002376
GO:0002674
GO:0003013
GO:0003674
GO:0005158
GO:0005159
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005975
GO:0006006
GO:0006091
GO:0006355
GO:0006464
GO:0006520
GO:0006521
GO:0006629
GO:0006810
GO:0006888
GO:0006950
GO:0006953
GO:0007049
GO:0007165
GO:0007186
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008286
GO:0009056
GO:0009058
GO:0010628
GO:0010750
GO:0014068
GO:0015031
GO:0016192
GO:0019899
GO:0022898
GO:0030133
GO:0030154
GO:0030307
GO:0030335
GO:0031410
GO:0031904
GO:0031954
GO:0032148
GO:0032270
GO:0032880
GO:0033116
GO:0033861
GO:0034330
GO:0034641
GO:0034774
GO:0038060
GO:0040007
GO:0040011
GO:0042060
GO:0042177
GO:0042311
GO:0042592
GO:0042593
GO:0042802
GO:0043226
GO:0043410
GO:0044281
GO:0045597
GO:0045721
GO:0045725
GO:0045818
GO:0045821
GO:0045840
GO:0045861
GO:0045922
GO:0046326
GO:0046628
GO:0046631
GO:0046889
GO:0048167
GO:0048856
GO:0048870
GO:0050708
GO:0050709
GO:0050877
GO:0050890
GO:0050995
GO:0051000
GO:0051092
GO:0051897
GO:0055085
GO:0055089
GO:0060266
GO:0060267
GO:0090277
GO:0090336
GO:0140014
GO:1900182
GO:1900273
GO:1902176
GO:1902952
GO:1903076
GO:1903427
GO:1990000
GO:1990535
GO:2000252
HMNXSV003049612
ILMN_1666966
J00268_s_at
PH_hs_0005022
PH_hs_0031401
V00565_s_at
g4557670_3p_at
Participates
as a component of
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
INS(57-87) [extracellular region]
INS(57-87) [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [Golgi membrane]
INS(90-110) [endosome lumen]
INS(25-54) [endosome lumen]
4xHC-INS(90-110) [extracellular region]
2xHC-INS(25-54) [extracellular region]
Modified Residues
Name
Replacement of residues 54 to 54 by TRR
Name
Inter-chain Crosslink via L-cystine (cross-link) at 31 and 96
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Inter-chain Crosslink via L-cystine (cross-link) at 43 and 109
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
3P2X, 4GBI, 2WS1, 6S4I, 2WBY, 1LPH, 2WC0, 5URT, 1XGL, 2KXK, 4UNG, 6Z7Y, 5WDM, 4OGA, 1TRZ, 2G54, 5UU3, 5CJO, 1ZNJ, 2OMQ, 6X4X, 3FQ9, 2JV1, 2JUV, 6VES, 5BPO, 1T1Q, 3V19, 3W7Y, 4F1F, 4F8F, 2WS4, 4EWX, 4IUZ, 5MHD, 5BOQ, 6P4Z, 4EYD, 6CE7, 6TC2, 3ZQR, 2LGB, 1QJ0, 1J73, 1HLS, 1SJT, 3ROV, 6B3Q, 3W11, 2OMI, 6TYH, 3W80, 2JUU, 4CXN, 1JCO, 1A7F, 5USS, 4F51, 4F0O, 4AIY, 5MT9, 2JUM, 5MWQ, 1ZEG, 6VEP, 2M2M, 2N2V, 2WS0, 6B70, 2KJU, 1T1P, 2MVD, 4XC4, 2WRV, 2MVC, 1TYL, 6GNQ, 2CEU, 3TT8, 1TYM, 2R35, 6SOF, 4F1C, 4EFX, 4GBN, 2R34, 6VET, 5CNY, 2M2P, 2L1Z, 2W44, 1LKQ, 2M1E, 2M2O, 3UTQ, 5HQI, 1SF1, 6GV0, 1KMF, 1HUI, 4IYF, 2HIU, 1JCA, 1T1K, 1QIZ, 2WRX, 5USV, 5URU, 3ZI3, 2WRU, 4RXW, 3U4N, 3ILG, 1QIY, 4GBL, 1HTV, 1VKT, 4AK0, 3W7Z, 5T7R, 2M1D, 4F4T, 5CO6, 5EN9, 2C8R, 1UZ9, 4Z76, 1HIT, 2AIY, 4Y1A, 1XW7, 1W8P, 4FKA, 6Z7W, 1AI0, 5HYJ, 2OM1, 6O17, 1XDA, 2HH4, 2K91, 6JR3, 3BXQ, 1OS4, 5BQQ, 2QIU, 4AJX, 4EYP, 6NWV, 3UTT, 3HYD, 1IOG, 5C0D, 5VIZ, 5UOZ, 2K9R, 2HHO, 4AJZ, 4EY1, 6CEB, 1IOH, 2L1Y, 4GBC, 5UU4, 4WDI, 2JMN, 4F1G, 4CY7, 1ZEH, 1MSO, 4EWZ, 5ENA, 2N2X, 6CE9, 2C8Q, 4EX1, 4NIB, 1HIQ, 2N2W, 4F1A, 6JK8, 4EYN, 1AIY, 2WRW, 2R36, 2VJZ, 1B9E, 1G7B, 6S4J, 1JK8, 1MHJ, 5HRQ, 5USP, 5MT3, 4UNH, 2KJJ, 4F1D, 1RWE, 3UTS, 6BFC, 3AIY, 4EXX, 1HIS, 1T0C, 2M2N, 4F4V, 3ZU1, 1MHI, 3EXX, 3P33, 5BTS, 5E7W, 1EV3, 6CK2, 2MPI, 2MLI, 4AKJ, 2OLY, 1OS3, 6H3M, 2OM0, 3I3Z, 4F1B, 5UQA, 3INC, 3IR0, 5MAM, 6K59, 2G56, 5UU2, 2OMH, 5HPU, 2WS7, 4IYD, 5WOB, 1EV6, 4EWW, 3ZS2, 2WS6, 5UDP, 4Z78, 2H67, 1EFE, 6S34, 1BEN, 4P65, 5CO9, 4EX0, 6HN5, 1SJU, 2LWZ, 2OLZ, 3Q6E, 3E7Y, 1K3M, 1G7A, 2MPG, 1EVR, 6VER, 4UNE, 4GBK, 2RN5, 3W13, 5WBT, 3V1G, 3I40, 1FU2, 5AIY, 3W12, 2VK0, 4CXL, 1Q4V, 5HPR, 5CO2, 4Y19, 3JSD, 4F0N, 6U46, 1GUJ, 2KQQ, 4Z77, 3KQ6, 4EY9, 2KQP, 5EMS, 1FUB, 2OMG, 2JZQ, 4FG3, 3E7Z
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  25 0.971 21
 UniProt:P06213-2 INSR      0.697 6
 UniProt:P14735-1 IDE      0.618 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:P0DPK4 NT2NC      0.556 3
 UniProt:Q07627 KRTAP1-1  1 0.556 3
 UniProt:A8MQ03 CRTP1      0.556 3
 IntAct:EBI-22310722 CCSB ORF ID      0.556 3
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