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C Peptide [secretory granule lumen]
Stable Identifier
R-HSA-265011
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
INS(57-87)
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Exocytosis of Insulin (Homo sapiens)
C Peptide [secretory granule lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Insulin processing (Homo sapiens)
Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)
C Peptide [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
COSMIC (genes):INS INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
Participates
as an output of
Carboxypeptidase E (rat Carboxypeptidase H) cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) (Homo sapiens)
Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)
as an input of
Exocytosis of Insulin (Homo sapiens)
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
6xHC-INS(25-110) [secretory granule lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
2xHC-INS(25-54) [extracellular region]
4xHC-INS(90-110) [extracellular region]
INS(25-54) [endosome lumen]
INS(90-110) [endosome lumen]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [Golgi membrane]
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01308 INS
20
6xHC-INS(25-110) [Golgi lumen]
(R-HSA-264890)
6xHC-INS(25-110) [secretory granule lumen]
(R-HSA-264984)
2xHC-INS(25-56) [secretory granule lumen]
(R-HSA-9023201)
INS(57-89) [secretory granule lumen]
(R-HSA-9023172)
4xHC-INS(57-110) [secretory granule lumen]
(R-HSA-9023174)
6xHC-INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-265075)
INS(57-87) [extracellular region]
(R-HSA-265157)
C Peptide [secretory granule lumen]
(R-HSA-265011)
4xHC-INS(90-110) [secretory granule lumen]
(R-HSA-264971)
2xHC-INS(25-54) [secretory granule lumen]
(R-HSA-264902)
INS(25-110) [endoplasmic reticulum lumen]
(R-HSA-264893)
Insulin Aspart B Chain [extracellular region]
(R-HSA-429393)
Insulin Humalog B Chain [extracellular region]
(R-HSA-429397)
Insulin Glulisine B Chain [extracellular region]
(R-HSA-429465)
2xHC-Myri-INS(25-53) [extracellular region]
(R-HSA-429343)
Insulin Glargine A Chain [extracellular region]
(R-HSA-429369)
Insulin Glargine B Chain [extracellular region]
(R-HSA-429347)
2xHC-INS(25-54) [extracellular region]
(R-HSA-74673)
4xHC-INS(90-110) [extracellular region]
(R-HSA-74672)
INS(25-54) [endosome lumen]
(R-HSA-141723)
0.971
21
UniProt:P06213-2 INSR
0.697
6
UniProt:P14735-1 IDE
0.618
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
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