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IL10 [extracellular region]
Stable Identifier
R-HSA-447125
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-10, IL10_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
CD163 mediating an anti-inflammatory response (Homo sapiens)
CD163 gene produces CD163 protein (Homo sapiens)
Glucocorticoid, IL6, IL10 [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
IL10 gene produces IL10 protein (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 dimer binds IL10RA:JAK1 (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimerizes (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xIL10RA:JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL10 dimer [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Interleukin-10 (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
IL10 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22301 IL10
Gene Names
IL10
Chain
signal peptide:1-18, chain:19-178
Reference Genes
BioGPS Gene:3586 IL10
COSMIC (genes):IL10 IL10
CTD Gene:3586 IL10
dbSNP Gene:3586 IL10
ENSEMBL:ENSG00000136634 IL10
HGNC:5962 IL10
KEGG Gene (Homo sapiens):3586 IL10
Monarch:3586 IL10
NCBI Gene:3586 IL10
OMIM:124092 IL10
Reference Transcript
RefSeq:NM_000572.2 IL10
Other Identifiers
0002970315
11734307_at
11734308_at
1548_s_at
16698684
207433_at
2452949
2452950
2452951
2452952
2452954
2452956
2452957
2452958
3586
7923907
A_23_P126735
GE61058
GO:0000003
GO:0000278
GO:0001818
GO:0001938
GO:0002237
GO:0002376
GO:0002719
GO:0002875
GO:0002904
GO:0003674
GO:0005125
GO:0005141
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0006259
GO:0006810
GO:0006914
GO:0006950
GO:0006955
GO:0007049
GO:0007155
GO:0007165
GO:0007253
GO:0007267
GO:0007568
GO:0008083
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0009790
GO:0010033
GO:0010468
GO:0010507
GO:0014823
GO:0014854
GO:0015031
GO:0019221
GO:0030097
GO:0030154
GO:0030183
GO:0030595
GO:0030886
GO:0030889
GO:0032496
GO:0032687
GO:0032689
GO:0032692
GO:0032695
GO:0032701
GO:0032715
GO:0032717
GO:0032720
GO:0032800
GO:0032868
GO:0034115
GO:0034116
GO:0034330
GO:0034465
GO:0034641
GO:0035722
GO:0035729
GO:0040011
GO:0042092
GO:0042100
GO:0042130
GO:0042493
GO:0042536
GO:0042742
GO:0042832
GO:0043032
GO:0043066
GO:0043524
GO:0045019
GO:0045191
GO:0045347
GO:0045348
GO:0045787
GO:0045893
GO:0045930
GO:0045944
GO:0046427
GO:0046983
GO:0048646
GO:0048856
GO:0048870
GO:0050715
GO:0050728
GO:0050807
GO:0050877
GO:0051045
GO:0051091
GO:0051384
GO:0051930
GO:0060302
GO:0060670
GO:0071222
GO:0071392
GO:0071650
GO:0072577
GO:0097421
GO:1902895
GO:1903034
GO:1903208
GO:1903672
GO:1904057
GO:1904706
GO:1904707
GO:2000352
ILMN_1674167
ILMN_2073307
PH_hs_0011425
TC01003766.hg
TC01006066.hg
U16720_rna1_s_at
g10835140_3p_at
Participant Of
output
Expression of Interleukin-10
IL10 gene produces IL10 protein
hasMember
Glucocorticoid, IL6, IL10 [extracellular region]
STAT3-upregulated extracellular proteins [extracellular region]
input
IL10 dimerizes
hasComponent
IL10 dimer [extracellular region]
This entity regulates
Negatively
IL10 negatively regulates extracellular inflammatory mediators
IL10 negatively regulates plasma membrane-associated inflammatory mediators
Positively
IL10 positively regulates extracellular inflammatory mediators
IL10 positively regulates plasma membrane-associated inflammatory mediators
Inferred To
Ghost homologue of IL10 [extracellular region] (Canis familiaris)
Ghost homologue of IL10 [extracellular region] (Danio rerio)
Ghost homologue of IL10 [extracellular region] (Gallus gallus)
Ghost homologue of IL10 [extracellular region] (Mus musculus)
Ghost homologue of IL10 [extracellular region] (Rattus norvegicus)
Ghost homologue of IL10 [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
NP_000563.1
OpenTargets
ENSG00000136634
HPA
ENSG00000136634-IL10
GeneCards
P22301
Ensembl
ENST00000423557
,
ENSG00000136634
,
ENSP00000412237
PRO
P22301
Orphanet
16253
PDB
1INR
,
2ILK
,
1ILK
,
1J7V
,
1Y6K
,
2H24
,
1LK3
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13651 IL10RA
3
p-Y496-IL10RA [plasma membrane]
(R-HSA-6784793)
IL10RA [plasma membrane]
(R-HSA-449841)
p-Y446-IL10RA [plasma membrane]
(R-HSA-6784810)
0.862
9
UniProt:Q08334 IL10RB
1
IL10RB [plasma membrane]
(R-HSA-448423)
0.589
2
UniProt:A0A087WY89 A0A087WY89
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P0DPK4 NT2NC
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
IntAct:EBI-22310722 CCSB ORF ID
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
3
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