Reactome | IL10 [extracellular region]

IL10 [extracellular region]

Stable Identifier

R-HSA-447125

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-10, IL10_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22301 IL10

Gene Names

IL10

Chain

signal peptide:1-18, chain:19-178

Reference Genes

BioGPS Gene:3586 IL10

COSMIC (genes):IL10 IL10

CTD Gene:3586 IL10

dbSNP Gene:3586 IL10

ENSEMBL:ENSG00000136634 IL10

HGNC:5962 IL10

KEGG Gene (Homo sapiens):3586 IL10

Monarch:3586 IL10

NCBI Gene:3586 IL10

OMIM:124092 IL10

Reference Transcript

RefSeq:NM_000572.2 IL10

Other Identifiers

0002970315

11734307_at

11734308_at

1548_s_at

16698684

207433_at

2452949

2452950

2452951

2452952

2452954

2452956

2452957

2452958

3586

7923907

A_23_P126735

GE61058

GO:0000003

GO:0000278

GO:0001818

GO:0001938

GO:0002237

GO:0002376

GO:0002719

GO:0002875

GO:0002904

GO:0003674

GO:0005125

GO:0005141

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006259

GO:0006810

GO:0006914

GO:0006950

GO:0006955

GO:0007049

GO:0007155

GO:0007165

GO:0007253

GO:0007267

GO:0007568

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009056

GO:0009058

GO:0009790

GO:0010033

GO:0010468

GO:0010507

GO:0014823

GO:0014854

GO:0015031

GO:0019221

GO:0030097

GO:0030154

GO:0030183

GO:0030595

GO:0030886

GO:0030889

GO:0032496

GO:0032687

GO:0032689

GO:0032692

GO:0032695

GO:0032701

GO:0032715

GO:0032717

GO:0032720

GO:0032800

GO:0032868

GO:0034115

GO:0034116

GO:0034330

GO:0034465

GO:0034641

GO:0035722

GO:0035729

GO:0040011

GO:0042092

GO:0042100

GO:0042130

GO:0042493

GO:0042536

GO:0042742

GO:0042832

GO:0043032

GO:0043066

GO:0043524

GO:0045019

GO:0045191

GO:0045347

GO:0045348

GO:0045787

GO:0045893

GO:0045930

GO:0045944

GO:0046427

GO:0046983

GO:0048646

GO:0048856

GO:0048870

GO:0050715

GO:0050728

GO:0050807

GO:0050877

GO:0051045

GO:0051091

GO:0051384

GO:0051930

GO:0060302

GO:0060670

GO:0071222

GO:0071392

GO:0071650

GO:0072577

GO:0097421

GO:1902895

GO:1903034

GO:1903208

GO:1903672

GO:1904057

GO:1904706

GO:1904707

GO:2000352

ILMN_1674167

ILMN_2073307

PH_hs_0011425

TC01003766.hg

TC01006066.hg

U16720_rna1_s_at

g10835140_3p_at

Participant Of

output

hasMember

input

IL10 dimerizes

hasComponent

IL10 dimer [extracellular region]

This entity regulates

Negatively

Positively

Inferred To

Ghost homologue of IL10 [extracellular region] (Canis familiaris)

Ghost homologue of IL10 [extracellular region] (Danio rerio)

Ghost homologue of IL10 [extracellular region] (Gallus gallus)

Ghost homologue of IL10 [extracellular region] (Mus musculus)

Ghost homologue of IL10 [extracellular region] (Rattus norvegicus)

Ghost homologue of IL10 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000563.1

OpenTargets

ENSG00000136634

HPA

ENSG00000136634-IL10

GeneCards

P22301

Ensembl

ENST00000423557, ENSG00000136634, ENSP00000412237

PRO

P22301

Orphanet

16253

PDB

1INR, 2ILK, 1ILK, 1J7V, 1Y6K, 2H24, 1LK3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13651 IL10RA	3	p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841) p-Y446-IL10RA [plasma membrane] (R-HSA-6784810)	0.862	9
UniProt:Q08334 IL10RB	1	IL10RB [plasma membrane] (R-HSA-448423)	0.589	2
UniProt:A0A087WY89 A0A087WY89			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P0DPK4 NT2NC			0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
IntAct:EBI-22310722 CCSB ORF ID			0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3

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