6xHC-INS(25-110) [secretory granule lumen]

Stable Identifier
R-HSA-264984
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Proinsulin (cystine bonded)
Icon
6xHC-INS(25-110) [secretory granule lumen] icon
6xHC-INS(25-110) [secretory granule lumen] icon
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P01308 INS
Gene Names
INS
Chain
signal peptide:1-24, peptide:25-54, propeptide:57-87, peptide:90-110
Reference Genes
BioGPS Gene:3630 INS
COSMIC (genes):INS INS
CTD Gene:3630 INS
dbSNP Gene:3630 INS
ENSEMBL:ENSG00000254647 INS
HGNC:6081 INS
KEGG:hsa:3630 INS
Monarch:3630 INS
NCBI Gene:3630 INS
OMIM:176730 INS
UCSC:P01308 INS
Reference Transcript
Participates
as a component of
Other forms of this molecule
6xHC-INS(25-110) [Golgi lumen]
2xHC-INS(25-56) [secretory granule lumen]
INS(57-89) [secretory granule lumen]
4xHC-INS(57-110) [secretory granule lumen]
6xHC-INS(25-110) [endoplasmic reticulum lumen]
INS(57-87) [extracellular region]
C Peptide [secretory granule lumen]
4xHC-INS(90-110) [secretory granule lumen]
2xHC-INS(25-54) [secretory granule lumen]
INS(25-110) [endoplasmic reticulum lumen]
Insulin Aspart B Chain [extracellular region]
Insulin Humalog B Chain [extracellular region]
Insulin Glulisine B Chain [extracellular region]
2xHC-Myri-INS(25-53) [extracellular region]
Insulin Glargine A Chain [extracellular region]
Insulin Glargine B Chain [extracellular region]
6xHC-INS(25-110) [Golgi membrane]
6xHC-INS(25-110) [transport vesicle]
6xHC-INS(25-110) [endoplasmic reticulum-Golgi intermediate compartment membrane]
INS(90-110) [endosome lumen]
INS(25-54) [endosome lumen]
2xHC-INS(25-54) [extracellular region]
4xHC-INS(90-110) [extracellular region]
Inferred To
Ins1 [secretory granule lumen] (Mus musculus)
Ins1 [secretory granule lumen] (Rattus norvegicus)
INS [secretory granule lumen] (Bos taurus)
INS [secretory granule lumen] (Canis familiaris)
INS [secretory granule lumen] (Gallus gallus)
INS [secretory granule lumen] (Sus scrofa)
ins [secretory granule lumen] (Danio rerio)
Ins2 [secretory granule lumen] (Mus musculus)
Ins2 [secretory granule lumen] (Rattus norvegicus)
Homologues of 6xHC-INS(25-110) [secretory granule lumen] (Mus musculus)
Homologues of 6xHC-INS(25-110) [secretory granule lumen] (Rattus norvegicus)
Ghost homologue of 6xHC-INS(25-110) [secretory granule lumen] (Xenopus tropicalis)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 31 and 96
Coordinate
31
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 43 and 109
Coordinate
43
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Name
Intra-chain Crosslink via L-cystine (cross-link) at 95 and 100
Coordinate
95
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
RefSeq
OpenTargets
ENSEMBL
GeneCards
INS
HPA
PRO
Pharos - Targets
Orphanet
INS
PDB
6SOF, 4FG3, 7QID, 4F4V, 3P33, 3TT8, 7YQ3, 1T1K, 2WRW, 5CJO, 1MHJ, 5HQI, 4GBI, 2JZQ, 1XGL, 2K9R, 5BOQ, 6HN5, 3AIY, 1T1Q, 4AJZ, 4EX0, 9LVD, 4IUZ, 1SF1, 7MD5, 5URT, 4F1B, 1HIS, 5MT9, 8WU0, 4AIY, 6JR3, 2MLI, 5CO9, 2R35, 3E7Y, 2OM1, 7BW7, 2M1D, 7SL1, 4P65, 6CEB, 3W13, 5WOB, 6VES, 5AIY, 2WS7, 3I40, 2WS0, 2RN5, 4UNE, 2OLY, 2KQP, 1IOH, 1MSO, 3W7Y, 4IYD, 3U4N, 5UDP, 1ZNJ, 5USV, 4EYD, 5UU3, 1VKT, 4F1A, 5HPU, 8ONP, 7MD4, 3KQ6, 2KXK, 7Z5L, 3EXX, 3ZQR, 1G7B, 5HPR, 8ONK, 3W12, 2M1E, 5EN9, 5E7W, 4F0N, 4AKJ, 9M50, 2VJZ, 2MPG, 7RZI, 5BQQ, 7PG4, 2OMI, 8HGZ, 1MHI, 1IOG, 6BFC, 4UNH, 2WS4, 7YQ4, 3UTQ, 4IYF, 1GUJ, 4EY9, 6GV0, 2HH4, 3ILG, 8SBD, 4EWX, 9LVC, 1EV3, 2N2X, 3ZS2, 1EFE, 2C8R, 6U46, 1LKQ, 4F1D, 1A7F, 2CEU, 6GNQ, 7Z5Q, 2G54, 2OM0, 1TRZ, 2JMN, 2L1Y, 3E7Z, 2WS6, 5MWQ, 5MHD, 2KJU, 2OMG, 9M4Z, 7NMG, 1LPH, 7STJ, 7SL7, 4OGA, 2WS1, 4F51, 3ROV, 2HIU, 8HSK, 3ZU1, 1HIQ, 3W7Z, 4UNG, 4EXX, 1T1P, 4EWW, 6CE7, 7QAC, 4EX1, 4EFX, 3JSD, 4F1C, 1G7A, 2JV1, 5USP, 1HUI, 5C0D, 1Q4V, 4CXL, 1EV6, 4XC4, 5T7R, 5VIZ, 7SL6, 8PJH, 8EZ0, 5UQA, 2L1Z, 5CO6, 6VEP, 2WRU, 4F0O, 7PG0, 8IPZ, 6H3M, 7MQR, 7RZE, 6O17, 7PG3, 1XW7, 4Z77, 5BPO, 8VCX, 3I3Z, 1TYM, 6JK8, 8VDD, 8RVT, 1JCO, 1AI0, 1BEN, 4NIB, 6P4Z, 7KD6, 4EWZ, 2M2N, 5UU2, 4F1G, 4CXN, 6S34, 4CY7, 7NHU, 1SJU, 5MAM, 3BXQ, 3ZI3, 2R34, 1B9E, 2M2O, 3P2X, 4FKA, 2JUV, 1FUB, 2VK0, 1OS4, 8PI4, 7S4Y, 8RRP, 5HRQ, 3FQ9, 6CK2, 7STH, 1T0C, 1ZEH, 2WRX, 6VER, 7RZF, 2OMH, 7PG2, 4Y1A, 4Z76, 4EYN, 4GBK, 4AK0, 6B3Q, 5HYJ, 4F8F, 2WBY, 4WDI, 5ENA, 4GBN, 8Z4B, 1XDA, 2KJJ, 8ONI, 1EVR, 2C8Q, 6B70, 3Q6E, 2JUM, 6X4X, 2MVD, 1W8P, 7SL4, 7BW8, 5EMS, 2OMQ, 2M2P, 1J73, 2G56, 8GSG, 2QIU, 6CE9, 4EYP, 2H67, 1HTV, 6NWV, 7STK, 1FU2, 9M51, 2LGB, 6S4J, 6VET, 7RKD, 7YQ5, 2AIY, 8HSF, 2WRV, 2OLZ, 2KQQ, 4EY1, 9LVE, 1KMF, 4RXW, 2K91, 4AJX, 7JP3, 5URU, 6TYH, 5BTS, 3V1G, 8GUY, 5UU4, 3HYD, 3W80, 9LVX, 2N2V, 3UTS, 5MT3, 1SJT, 2R36, 8ONR, 4F1F, 5CNY, 1HIT, 1JCA, 2W44, 6Z7Y, 7SL3, 2MPI, 1OS3, 1K3M, 1QIY, 7BWA, 8OKY, 4F4T, 9M4X, 8EYY, 3INC, 8PI6, 4Y19, 6S4I, 1RWE, 7MQO, 1ZEG, 2LWZ, 1JK8, 2WC0, 4Z78, 1TYL, 5USS, 4GBC, 7QGF, 1UZ9, 4GBL, 5WBT, 3V19, 3UTT, 2M2M, 9LVY, 2N2W, 7SL2, 3IR0, 6Z7W, 2MVC, 5CO2, 7U6E, 3W11, 8EYX, 2HHO, 6TC2, 1HLS, 5WDM, 7MQS, 2JUU, 8PI5, 7V3P, 1QIZ, 7STI, 1AIY, 6K59, 9M4Y, 1QJ0, 5UOZ
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01308 INS  20 0.971 21
 UniProt:P06213-2 INSR      0.697 6
 UniProt:P14735-1 IDE      0.618 3
 UniProt:Q6UY14-3 ADAMTSL4      0.556 3
 UniProt:P0DPK4 NOTCH2NLC  1 0.556 3
 UniProt:Q8IUG1 KRTAP1-3  1 0.556 3
 UniProt:Q07627 KRTAP1-1  1 0.556 3
 UniProt:A8MQ03 CRTP1      0.556 3
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