Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FarC-PTP4A2 [cytosol]
Stable Identifier
R-HSA-8870421
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein tyrosine phosphatase type IVA 2 ecNumber3.1.3.48/ecNumber, TP4A2_HUMAN, PRL2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
RAB geranylgeranylation (Homo sapiens)
FarC-PTP4A2 binds RABGGTB (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
RABGGTA and RABGGTB bind (Homo sapiens)
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11447212
Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II
Hong, W
,
Si, X
,
Ng, CH
,
Pallen, CJ
,
Zeng, Q
J. Biol. Chem.
2001
External Reference Information
External Reference
UniProt:Q12974 PTP4A2
Gene Names
PTP4A2, PRL2, PTPCAAX2, BM-008
Chain
chain:1-164, propeptide:165-167
Reference Genes
BioGPS Gene:8073 PTP4A2
COSMIC (genes):PTP4A2 PTP4A2
CTD Gene:8073 PTP4A2
dbSNP Gene:8073 PTP4A2
ENSEMBL:ENSG00000184007 PTP4A2
HGNC:9635 PTP4A2
Monarch:8073 PTP4A2
NCBI Gene:8073 PTP4A2
OMIM:601584 PTP4A2
UCSC:Q12974 PTP4A2
Reference Transcript
RefSeq:XM_005271232.3 PTP4A2
RefSeq:XM_017002401.1 PTP4A2
RefSeq:NM_001195100.1 PTP4A2
RefSeq:NM_080391.3 PTP4A2
RefSeq:NM_001195101.1 PTP4A2
RefSeq:XM_005271231.3 PTP4A2
Other Identifiers
11742465_x_at
11743268_a_at
11757440_x_at
11759479_s_at
11759480_s_at
1241_at
16684614
208615_PM_s_at
208615_s_at
208616_PM_s_at
208616_s_at
208617_PM_s_at
208617_s_at
216988_PM_s_at
216988_s_at
2404820
2404821
2404822
2404823
2404824
2404825
2404828
2404829
2404830
2404831
2404832
2404833
2404836
2404837
2404838
2404839
2404840
2404841
2404842
2404844
2404847
2404849
2404852
2404853
2404854
2404855
2404861
3399533
3399535
3399536
3721788
3721790
3721791
38415_at
7914489
8073
A_23_P11713
A_23_P378968
A_24_P188460
GO:0003824
GO:0004721
GO:0004725
GO:0005515
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006470
GO:0016311
GO:0016787
GO:0031410
GO:0043226
GO:0140096
HMNXSV003032466
Hs.82911.0.S2_3p_a_at
Hs.82911.1.S1_3p_a_at
ILMN_1670972
ILMN_1688490
ILMN_1689197
ILMN_1795697
ILMN_2338997
PH_hs_0004741
TC01002461.hg
TC01005384.hg
U14603_at
g1777756_3p_a_at
g7582287_3p_a_at
Participates
as an input of
FarC-PTP4A2 binds RABGGTB (Homo sapiens)
as a component of
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
Inferred To
PTP4A2 [cytosol]
(Bos taurus)
PTP4A2 [cytosol]
(Canis familiaris)
PTP4A2 [cytosol]
(Gallus gallus)
FarC-PTP4A2 [cytosol]
(Dictyostelium discoideum)
FarC-PTP4A2 [cytosol]
(Mus musculus)
FarC-PTP4A2 [cytosol]
(Plasmodium falciparum)
FarC-PTP4A2 [cytosol]
(Rattus norvegicus)
FarC-PTP4A2 [cytosol]
(Sus scrofa)
Homologues of FarC-PTP4A2 [cytosol]
(Dictyostelium discoideum)
ptp4a2b [cytosol]
(Danio rerio)
ptp4a2 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
S-farnesyl-L-cysteine at 164
Coordinate
164
PsiMod Name
S-farnesyl-L-cysteine [MOD:00111]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.
Cross References
OpenTargets
ENSG00000184007
ENSEMBL
ENSP00000473259
,
ENSP00000497092
,
ENST00000457805
,
ENST00000647444
,
ENST00000602725
,
ENSP00000493688
,
ENSP00000409260
,
ENST00000602683
,
ENST00000649841
,
ENSP00000473490
IntEnz
3.1.3.48
HPA
ENSG00000184007-PTP4A2
ZINC - Substances
TP4A2_HUMAN
ZINC target
Q12974
PRO
Q12974
Pharos - Targets
Q12974
ZINC - Predictions - Purchasable
TP4A2_HUMAN
PDB
5K23
,
5K22
,
5K25
,
6WUR
HMDB Protein
HMDBP08959
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRU3 CNNM1
0.759
6
UniProt:Q6P4Q7 CNNM4
0.745
6
UniProt:Q93096 TP4A1
0.744
5
UniProt:Q8NE01 CNNM3
0.695
5
UniProt:O75365 TP4A3
0.643
3
UniProt:Q9H8M5 CNNM2
0.569
4
UniProt:P49354 FNTA
3
FNTA(59-379) [cytosol]
(R-HSA-202872)
FNTA(1-59) [cytosol]
(R-HSA-202869)
FNTA(2-379) [cytosol]
(R-HSA-2530516)
0.564
2
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
2
UniProt:O43292 GPAA1
1
GPAA1 [endoplasmic reticulum membrane]
(R-HSA-162727)
0.527
2
UniProt:Q9Y5E4 PCDB5
0.527
2
UniProt:Q9NZ56 FMN2
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text