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FarC-PTP4A2 [cytosol]
Stable Identifier
R-HSA-8870421
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein tyrosine phosphatase type IVA 2 ecNumber3.1.3.48/ecNumber, TP4A2_HUMAN, PRL2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
RAB geranylgeranylation (Homo sapiens)
FarC-PTP4A2 binds RABGGTB (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
RABGGTA and RABGGTB bind (Homo sapiens)
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
FarC-PTP4A2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11447212
Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II
Hong, W
,
Si, X
,
Ng, CH
,
Pallen, CJ
,
Zeng, Q
J. Biol. Chem.
2001
External Reference Information
External Reference
UniProt:Q12974 PTP4A2
Gene Names
PTP4A2, PRL2, PTPCAAX2, BM-008
Chain
chain:1-164, propeptide:165-167
Reference Genes
BioGPS Gene:8073 PTP4A2
COSMIC (genes):PTP4A2 PTP4A2
CTD Gene:8073 PTP4A2
dbSNP Gene:8073 PTP4A2
ENSEMBL:ENSG00000184007 PTP4A2
HGNC:9635 PTP4A2
KEGG Gene (Homo sapiens):8073 PTP4A2
Monarch:8073 PTP4A2
NCBI Gene:8073 PTP4A2
OMIM:601584 PTP4A2
UCSC:Q12974 PTP4A2
Reference Transcript
RefSeq:XM_017002401.1 PTP4A2
RefSeq:XM_005271232.3 PTP4A2
RefSeq:NM_001195100.1 PTP4A2
RefSeq:NM_001195101.1 PTP4A2
RefSeq:XM_005271231.3 PTP4A2
RefSeq:NM_080391.3 PTP4A2
Other Identifiers
0003870609
0006370458
11742465_x_at
11743268_a_at
11757440_x_at
11759479_s_at
11759480_s_at
1241_at
16684614
208615_s_at
208616_s_at
208617_s_at
216988_s_at
2404820
2404821
2404822
2404823
2404824
2404825
2404828
2404832
2404833
2404837
2404839
2404840
2404841
2404842
2404847
2404853
2404854
2404855
3399533
3399535
3399536
3721788
3721790
3721791
38415_at
7914489
8073
A_23_P11713
A_23_P378968
A_24_P188460
GO:0003674
GO:0004721
GO:0004725
GO:0004727
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006464
GO:0006470
GO:0008150
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0031410
GO:0035335
GO:0043226
GO:0043687
HMNXSV003032466
Hs.82911.0.S2_3p_a_at
Hs.82911.1.S1_3p_a_at
ILMN_1670972
ILMN_2338997
PH_hs_0004741
TC01002461.hg
TC01005384.hg
U14603_at
g1777756_3p_a_at
g7582287_3p_a_at
Participates
as an input of
FarC-PTP4A2 binds RABGGTB (Homo sapiens)
as a component of
FarC-PTP4A2:RABGGTB [cytosol] (Homo sapiens)
Inferred To
PTP4A2 [cytosol]
(Bos taurus)
PTP4A2 [cytosol]
(Canis familiaris)
PTP4A2 [cytosol]
(Gallus gallus)
PTP4A2 [cytosol]
(Sus scrofa)
ptp4a2a [cytosol]
(Danio rerio)
FarC-PTP4A2 [cytosol]
(Dictyostelium discoideum)
FarC-PTP4A2 [cytosol]
(Plasmodium falciparum)
Homologues of FarC-PTP4A2 [cytosol]
(Danio rerio)
ptp4a2b [cytosol]
(Danio rerio)
PRL-1 [cytosol]
(Caenorhabditis elegans)
PRL-1 [cytosol]
(Drosophila melanogaster)
ptp4a2 [cytosol]
(Xenopus tropicalis)
Ptp4a2 [cytosol]
(Mus musculus)
Ptp4a2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
S-farnesyl-L-cysteine at 164
Coordinate
164
PsiMod Name
S-farnesyl-L-cysteine [MOD:00111]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.
Cross References
RefSeq
XP_005271289.1
,
XP_005271288.1
,
XP_016857890.1
,
NP_536316.1
,
NP_001182029.1
,
NP_001182030.1
OpenTargets
ENSG00000184007
ZINC - Substances
TP4A2_HUMAN
ZINC target
Q12974
PRO
Q12974
PDB
5K25
,
5K22
,
6WUR
,
5K23
IntEnz
3.1.3.48
GeneCards
Q12974
HPA
ENSG00000184007-PTP4A2
Ensembl
ENSP00000473490
,
ENST00000647444
,
ENSP00000473259
,
ENSP00000493688
,
ENST00000602725
,
ENSG00000184007
,
ENSP00000497092
,
ENST00000602683
,
ENST00000457805
,
ENSP00000409260
,
ENST00000649841
Pharos - Targets
Q12974
ZINC - Predictions - Purchasable
TP4A2_HUMAN
HMDB Protein
HMDBP08959
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRU3 CNNM1
0.691
5
UniProt:Q6P4Q7 CNNM4
0.671
4
UniProt:Q93096 TP4A1
0.669
3
UniProt:Q8NE01 CNNM3
0.604
3
UniProt:O75365 TP4A3
0.527
2
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