10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-1467382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Fuc-Pre-NOTCH3, Fucosylated NOTCH3 receptor precursor
Icon
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] icon
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q9UM47 NOTCH3
Gene Names
NOTCH3
Chain
signal peptide:1-39, chain:40-2321, chain:1629-2321, chain:1662-2321
Reference Genes
BioGPS Gene:4854 NOTCH3
COSMIC (genes):NOTCH3 NOTCH3
CTD Gene:4854 NOTCH3
dbSNP Gene:4854 NOTCH3
ENSEMBL:ENSG00000074181 NOTCH3
HGNC:7883 NOTCH3
KEGG:hsa:4854 NOTCH3
Monarch:4854 NOTCH3
NCBI Gene:4854 NOTCH3
OMIM:600276 NOTCH3
UCSC:Q9UM47 NOTCH3
Reference Transcript
Other Identifiers
11716569_at
11716570_a_at
16869769
203237_PM_s_at
203237_s_at
203238_PM_s_at
203238_s_at
3853111
3853112
3853113
3853114
3853115
3853116
3853117
3853118
3853119
3853120
3853121
3853122
3853123
3853124
3853125
3853126
3853127
3853128
3853129
3853130
3853131
3853132
3853133
3853134
3853135
3853136
3853137
3853138
3853139
3853140
3853141
3853142
3853143
3853144
3853145
3853146
3853147
3853148
3853150
3853151
3853152
3853153
3853154
3853157
3853158
3853159
3853160
3853161
3853162
3853163
3853164
3853166
3853167
3853168
3853169
3853170
3853173
3853174
3853175
38750_at
4854
8034940
A_33_P3313055
GE79373
GO:0000122
GO:0000139
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006355
GO:0007219
GO:0007275
GO:0007411
GO:0009986
GO:0014016
GO:0016020
GO:0019899
GO:0030154
GO:0030182
GO:0030900
GO:0038023
GO:0042802
GO:0043226
GO:0043235
GO:0045296
GO:0045596
GO:0045665
GO:0045944
GO:0048661
GO:0048663
GO:0048844
GO:0048856
GO:0050793
GO:0060089
GO:0072104
GO:1902895
HMNXSV003010299
HMNXSV003040803
Hs.8546.0.A1_3p_a_at
ILMN_1658926
PH_hs_0000907
TC19001250.hg
g4557798_3p_a_at
Participates
as a candidate of
Other forms of this molecule
Ub-NICD3 [cytosol]
Ub-NEXT3 [plasma membrane]
p-Y-NICD3 [cytosol]
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
NOTCH3(1572-2321) [Golgi membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
NOTCH3(1572-2321) [plasma membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
Pre-NOTCH3 [endoplasmic reticulum membrane]
NICD3 [nucleoplasm]
NICD3 [cytosol]
NEXT3 [plasma membrane]
NOTCH3(1629-1661) [plasma membrane]
NOTCH3(40-1628) [extracellular region]
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Modified Residues
Name
O-fucosyl-L-threonine at 173
Coordinate
173
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 211
Coordinate
211
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 250
Coordinate
250
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 290
Coordinate
290
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 328
Coordinate
328
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 445
Coordinate
445
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 671
Coordinate
671
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 748
Coordinate
748
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 863
Coordinate
863
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 938
Coordinate
938
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 1098
Coordinate
1098
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 1136
Coordinate
1136
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 1181
Coordinate
1181
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 1349
Coordinate
1349
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (18)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9NWT6 HIF1AN  1 0.643 5
 UniProt:Q9UM47 NOTCH3  20 0.558 2
 UniProt:P86480 PR20D      0.556 3
 UniProt:O60637 TSN3      0.527 2
 UniProt:P59665 DEFA1  9 0.527 2
 UniProt:Q9NZL3 ZNF224  1 0.527 2
 UniProt:Q8IXB1 DJC10      0.527 2
 UniProt:Q06330 RBPJ  1 0.527 2
 UniProt:Q9BZ11 ADAM33  1 0.527 2
 UniProt:Q8TC27 ADA32      0.527 2
 UniProt:Q9H8J5 MANS1      0.527 2
 UniProt:Q8N8Y5 ZFP41      0.527 2
 UniProt:Q9H9D4 ZN408      0.527 2
 UniProt:Q8WUM9 SLC20A1  1 0.527 2
 UniProt:P15260 IFNGR1  2 0.527 2
 UniProt:Q9Y3R4 NEU2  1 0.527 3
 UniProt:P53611 RABGGTB  2 0.527 2
 UniProt:Q9R1P4 Psma1  2 0.508 2
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