Reactome | PIP5K1C [cytosol]

PIP5K1C [cytosol]

Stable Identifier

R-HSA-392427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PIP5K1gamma

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 binds to PIP5K1C (Homo sapiens)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:PIP5K1C [Golgi membrane] (Homo sapiens)
        
        PIP5K1C [cytosol] (Homo sapiens)
        
        PIP5K1C [cytosol] (Homo sapiens)
        
        CDH1 translocates to the plasma membrane (Homo sapiens)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:PIP5K1C [Golgi membrane] (Homo sapiens)
        
        PIP5K1C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60331 PIP5K1C

Gene Names

PIP5K1C, KIAA0589

Chain

chain:1-668

Reference Genes

BioGPS Gene:23396 PIP5K1C

COSMIC - genes:PIP5K1C PIP5K1C

CTD Gene:23396 PIP5K1C

dbSNP Gene:23396 PIP5K1C

ENSEMBL:ENSG00000186111 PIP5K1C

HGNC:8996 PIP5K1C

KEGG:hsa:23396 PIP5K1C

Monarch:23396 PIP5K1C

NCBI Gene:23396 PIP5K1C

OMIM:606102 PIP5K1C

UCSC:O60331 PIP5K1C

Reference Transcript

Participates

as a component of

as an input of

CDH1 binds to PIP5K1C (Homo sapiens)

as a member of

Inferred To

sktl [cytosol] (Drosophila melanogaster)

PIPkinA [cytosol] (Dictyostelium discoideum)

Homologues of PIP5K1C [cytosol] (Dictyostelium discoideum)

Homologues of PIP5K1C [cytosol] (Drosophila melanogaster)

pip5k1c [cytosol] (Xenopus tropicalis)

MSS4 [cytosol] (Saccharomyces cerevisiae)

PIP5K59B [cytosol] (Drosophila melanogaster)

rpkA [cytosol] (Dictyostelium discoideum)

its3 [cytosol] (Schizosaccharomyces pombe)

PIP5K1C [cytosol] (Bos taurus)

PIP5K1C [cytosol] (Canis familiaris)

PIP5K1C [cytosol] (Dictyostelium discoideum)

PIP5K1C [cytosol] (Gallus gallus)

PIP5K1C [cytosol] (Plasmodium falciparum)

PIP5K1C [cytosol] (Sus scrofa)

Pip5k1c [cytosol] (Mus musculus)

Pip5k1c [cytosol] (Rattus norvegicus)

ppk-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_047294489.1, NP_036530.1, NP_001182662.1, XP_054176363.1, NP_001287778.1

ZINC - World Drugs

PI51C_HUMAN

Guide to Pharmacology - Targets

2165

OpenTargets

ENSG00000186111

ENSEMBL

ENSP00000335333, ENSG00000186111, ENSP00000466363, ENST00000539785, ENSP00000444779, ENSP00000445992, ENST00000589578, ENST00000335312, ENST00000537021

ZINC - FDA approved

PI51C_HUMAN

ZINC - Substances

PI51C_HUMAN

ZINC target

O60331

ZINC - Biogenic

PI51C_HUMAN

PRO

O60331

GlyGen

O60331

PDB

3H1Z, 2G35, 3H85

ZINC - Investigational

PI51C_HUMAN

IntEnz

2.7.1.68

HPA

ENSG00000186111-PIP5K1C

GeneCards

PIP5K1C

Pharos - Targets

O60331

Orphanet

PIP5K1C

ZINC - Predictions - Purchasable

PI51C_HUMAN

HMDB Protein

HMDBP03290

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.611	8
UniProt:P53611 RABGGTB	2	RABGGTB [plasma membrane] (R-HSA-6801098) RABGGTB [cytosol] (R-HSA-8870419)	0.527	2

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