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PIP5K1C [cytosol]
Stable Identifier
R-HSA-392427
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIP5K1gamma
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PIP5K1gamma:Talin-1 [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Homo sapiens)
PIP5K1C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60331 PIP5K1C
Gene Names
PIP5K1C, KIAA0589
Chain
chain:1-668
Reference Genes
COSMIC (genes):PIP5K1C PIP5K1C
dbSNP Gene:23396 PIP5K1C
ENSEMBL:ENSG00000186111 PIP5K1C
Participates
as a component of
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
PIP5K1gamma:Talin-1 [cytosol] (Homo sapiens)
as a member of
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
Inferred To
PIPkinA [cytosol]
(Dictyostelium discoideum)
Homologues of PIP5K1C [cytosol]
(Dictyostelium discoideum)
pip5k1c [cytosol]
(Xenopus tropicalis)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
PIP5K59B [cytosol]
(Drosophila melanogaster)
its3 [cytosol]
(Schizosaccharomyces pombe)
PIP5K1C [cytosol]
(Bos taurus)
PIP5K1C [cytosol]
(Canis familiaris)
PIP5K1C [cytosol]
(Dictyostelium discoideum)
PIP5K1C [cytosol]
(Gallus gallus)
PIP5K1C [cytosol]
(Plasmodium falciparum)
PIP5K1C [cytosol]
(Sus scrofa)
Pip5k1c [cytosol]
(Mus musculus)
Pip5k1c [cytosol]
(Rattus norvegicus)
ppk-1 [cytosol]
(Caenorhabditis elegans)
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y490 TLN1
4
TLN1 [extracellular region]
(R-HSA-350693)
TLN1(434-2541) [cytosol]
(R-HSA-9855156)
TLN1(1-433) [cytosol]
(R-HSA-9855031)
TLN1 [cytosol]
(R-HSA-350713)
0.611
8
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
2
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