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CEBPA [nucleoplasm]
Stable Identifier
R-HSA-381289
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CCAAT/enhancer-binding protein alpha, CEBPA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA binds CDK2 (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA:CDK2 [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds CDK4 (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA:CDK4 [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds CDKN1A (p21) (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA:CDKN1A [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds MYC gene:E2F1 (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds the promoter of the CEBPE gene (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPE gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds the promoter of the GFI1 gene (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
GFI1 gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA binds the promoter of the KLF5 gene (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
KLF5 gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)
CEBPE gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK (Homo sapiens)
CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
GFI1 gene expression is enhanced by CEBPA (Homo sapiens)
GFI1 gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
KLF5 gene expression is enhanced by CEBPA (Homo sapiens)
KLF5 gene:CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
CSF3R gene:SPI1:CEPBA dimer:DEK [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
Expression of GLUT4 (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
Expression of PPARG (Homo sapiens)
CEBPA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49715 CEBPA
Gene Names
CEBPA, CEBP
Chain
chain:1-358
Reference Genes
BioGPS Gene:1050 CEBPA
COSMIC (genes):CEBPA CEBPA
CTD Gene:1050 CEBPA
dbSNP Gene:1050 CEBPA
ENSEMBL:ENSG00000245848 CEBPA
HGNC:1833 CEBPA
KEGG Gene (Homo sapiens):1050 CEBPA
Monarch:1050 CEBPA
NCBI Gene:1050 CEBPA
OMIM:116897 CEBPA
UCSC:P49715 CEBPA
Reference Transcript
RefSeq:NM_001285829.1 CEBPA
RefSeq:NM_001287435.1 CEBPA
RefSeq:NM_001287424.1 CEBPA
RefSeq:NM_004364.4 CEBPA
Other Identifiers
0006400403
1050
11726294_s_at
16871235
204039_at
32550_r_at
3858994
3858995
3858996
3858997
3858998
3858999
3859000
3859001
3859002
3859003
3859004
61119_at
8036004
A_23_P375494
A_24_P216165
A_24_P224727
GE60289
GO:0000003
GO:0000050
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001889
GO:0001892
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0006091
GO:0006355
GO:0006357
GO:0006464
GO:0006629
GO:0006950
GO:0007005
GO:0007049
GO:0007165
GO:0007219
GO:0007275
GO:0008134
GO:0008150
GO:0008203
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0009790
GO:0010628
GO:0016032
GO:0019221
GO:0019899
GO:0019900
GO:0021700
GO:0030099
GO:0030154
GO:0030225
GO:0030324
GO:0030851
GO:0032436
GO:0032991
GO:0034641
GO:0042127
GO:0042592
GO:0042593
GO:0042802
GO:0042803
GO:0043032
GO:0043226
GO:0043231
GO:0043565
GO:0044281
GO:0044403
GO:0045444
GO:0045600
GO:0045669
GO:0045736
GO:0045786
GO:0045892
GO:0045893
GO:0045944
GO:0045945
GO:0048469
GO:0048839
GO:0048856
GO:0050729
GO:0050872
GO:0050873
GO:0055088
GO:0070102
GO:0071285
GO:0071356
GO:0071407
GO:0071941
GO:0090575
HMNXSV003010716
ILMN_1715715
PH_hs_0004394
TC19001396.hg
TC19002442.hg
U34070_s_at
Participates
as an input of
CEBPA binds the promoter of the GFI1 gene (Homo sapiens)
CEBPA binds CDK2 (Homo sapiens)
SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)
CEBPA binds CDK4 (Homo sapiens)
CEBPA binds the promoter of the CEBPE gene (Homo sapiens)
CEBPA binds CDKN1A (p21) (Homo sapiens)
CEBPA binds the promoter of the KLF5 gene (Homo sapiens)
CEBPA binds MYC gene:E2F1 (Homo sapiens)
as a component of
CEBPA:CDK2 [nucleoplasm] (Homo sapiens)
CEBPA:CDK4 [nucleoplasm] (Homo sapiens)
CEBPA:CDKN1A [nucleoplasm] (Homo sapiens)
CEBPA dimer [nucleoplasm] (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
as an output of
CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)
Expression of CEBPA (Homo sapiens)
This entity regulates
Positively
IL6R gene expression is enhanced by CEBPA
(Homo sapiens)
CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA
(Homo sapiens)
Expression of GLUT4
(Homo sapiens)
Expression of Leptin
(Homo sapiens)
Expression of PPARG
(Homo sapiens)
Expression of Adiponectin
(Homo sapiens)
Inferred To
CEBPA [nucleoplasm]
(Canis familiaris)
CEBPA [nucleoplasm]
(Gallus gallus)
CEBPA [nucleoplasm]
(Sus scrofa)
Cebpa [nucleoplasm]
(Mus musculus)
Cebpa [nucleoplasm]
(Rattus norvegicus)
Mabi [nucleoplasm]
(Drosophila melanogaster)
cebpa [nucleoplasm]
(Danio rerio)
slbo [nucleoplasm]
(Drosophila melanogaster)
Homologues of CEBPA [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001274364.1
,
NP_001274353.1
,
NP_004355.2
,
NP_001272758.1
OpenTargets
ENSG00000245848
HPA
ENSG00000245848-CEBPA
GeneCards
P49715
Ensembl
ENSP00000427514
,
ENSG00000245848
,
ENST00000498907
PRO
P49715
Pharos - Targets
P49715
Orphanet
19235
PDB
6DC0
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18848 ATF4
1
ATF4 [nucleoplasm]
(R-HSA-381016)
0.623
4
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.623
4
UniProt:P49715 CEBPA
1
CEBPA [nucleoplasm]
(R-HSA-381289)
0.623
2
UniProt:Q16520 BATF
1
BATF [nucleoplasm]
(R-HSA-6789925)
0.623
3
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.623
4
UniProt:Q9Y2D1 ATF5
1
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.623
2
UniProt:P06422 VE2
0.602
4
UniProt:P47902 CDX1
0.581
3
UniProt:P24001-2 IL32
0.576
7
UniProt:P03122 VE2
0.544
2
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.499
2
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