ATF3 binding to CD274 gene

Stable Identifier
R-HSA-9909594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATF3 binding to CD274 gene
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cAMP-dependent transcription factor 3 (ATF3) is an ATF/cAMP-responsive element-binding protein (CREB) family member whose expression is rapidly induced by a wide range of cellular stresses, including DNA damage, cellular injury, and oxidative stress (Liu et al. 2020). ATF3 regulates CD274 (PD-L1) transcription by binding to the PD-L1 promoter directly, inducing its transcription. (Liu et al., 2020, Liu et al., 2023).
Literature References
PubMed ID Title Journal Year
32183950 ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

Liu, H, Kuang, X, Zhang, Y, Ye, Y, Li, J, Liang, L, Xie, Z, Weng, L, Guo, J, Li, H, Ma, F, Chen, X, Zhao, S, Su, J, Yang, N, Fang, F, Xie, Y, Tao, J, Zhang, J, Chen, M, Peng, C, Sun, L, Zhang, X, Liu, J, Han, L, Xu, X, Hung, MC, Chen, X

Cancer Cell 2020
37678921 Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis

Liu, N, Yan, M, Tao, Q, Wu, J, Chen, J, Chen, X, Peng, C

J Immunother Cancer 2023
Participants
Input
Output
Participates
as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-05-14)
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