Expression of ATF3

Stable Identifier
Reaction [omitted]
Homo sapiens
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The ATF3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Chen et al. 2004, Pan et al. 2007, Lee et al. 2008, Armstrong et al. 2010, Sikalidis et al. 2011, Fu and Kilberg 2013, Lee et al. 2013, Hayner et al. 2018). Transcription of ATF3 is enhanced in response to amino acid deficiency (Chen et al. 2004, Pan et al. 2007, Lee et al. 2008, Sikaldis et al. 2011, Fu and Kilberg 2013, Hayner et al. 2018). ATF4 binds a CEBP-ATF response element (CARE) and an additional upstream element in the promoter of the ATF3 gene, resulting in enhanced transcription (Pan et al. 2007, Armstrong et al. 2010, Fu and Kilberg 2013, Lee et al. 2013, Hayner et al. 2018, and inferred from mouse homologs). CEBPB and ATF3 bind later and correlate with reduced expression of ATF4 (Pan et al. 2007)
Literature References
PubMed ID Title Journal Year
18285520 HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway

Dominy, JE, Sikalidis, AK, Lee, JI, Stipanuk, MH, Hirschberger, LL, Wang, W

Physiol. Genomics 2008
23269699 Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response

Kilberg, MS, Fu, L

Physiol. Genomics 2013
16989641 Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation

Kilberg, MS, Pan, YX, Chen, H, Thiaville, MM

Biochem. J. 2007
20022965 Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells

Lovat, PE, Veal, GJ, Redfern, CP, Armstrong, JL, Flockhart, R

J Biol Chem 2010
20361218 Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

Sikalidis, AK, Lee, JI, Stipanuk, MH

Amino Acids 2011
29413899 Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells

Kilberg, MS, Hayner, JN, Shan, J

Biochim Biophys Acta Gene Regul Mech 2018
15385533 Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation

Kilberg, MS, Pan, YX, Chen, H, Dudenhausen, EE

J. Biol. Chem. 2004
22819556 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells

Zhang, X, Lee, SH, Baek, SJ, Min, KW

J. Nutr. Biochem. 2013
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