Reactome | Transcriptional activation of mitochondrial biogenesis

Transcriptional activation of mitochondrial biogenesis

Stable Identifier

R-HSA-2151201

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, nucleoplasm, mitochondrial matrix

ReviewStatus

5/5

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Transcriptional activation of mitochondrial biogenesis

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Phosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate the transcription of nuclear-encoded, mitochondrially targeted proteins such as TFB2M, TFB1M, and TFAM. PGC-1beta and PPRC appear to act similarly to PGC-1alpha but have not been as well studied. Transcription of PPARGC1A itself is upregulated by CREB1 (in response to calcium), MEF2C/D, ATF2, and PPARGC1A. Transcription of PPARGC1A is repressed by NR1D1 (REV-ERBA).

Literature References

PubMed ID	Title	Journal	Year
19575678	Transcriptional control of mitochondrial biogenesis and function Hock, MB, Kralli, A	Annu Rev Physiol	2009
22265687	Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes Piantadosi, CA, Suliman, HB	Biochim. Biophys. Acta	2012
19682549	Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging Ljubicic, V, Joseph, AM, Saleem, A, Uguccioni, G, Collu-Marchese, M, Lai, RY, Nguyen, LM, Hood, DA	Biochim Biophys Acta	2010
20933024	Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network Scarpulla, RC	Biochim Biophys Acta	2011
22817841	Transcriptional integration of mitochondrial biogenesis Scarpulla, RC, Vega, RB, Kelly, DP	Trends Endocrinol. Metab.	2012