Expression of CYCS

Stable Identifier
R-HSA-1592231
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Synonyms
Expression of Cytochrome c
ReviewStatus
5/5
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Expression of CYCS
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The gene encoding cytochrome c (CYCS) is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield the precursor of cytochrome c, which is then imported into the mitochodrial matrix and associates with the matrix face of the inner membrane. As inferred from rat, PGC-1beta activates expression of cytochrome c (CYCS) (Lin et al. 2003). ERR1 (ERRalpha) probably interacts with coactivator PGC-1beta to activate expression of cytochrome c (CYCS) (Shao et al. 2010).
Literature References
PubMed ID Title Journal Year
16908542 PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth

Pasko, RA, Marino, VM, Gleyzer, N, Scarpulla, RC, Vercauteren, K

Mol Cell Biol 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
Regulator
ESRRA [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
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