Reactome | NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter

NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter

Stable Identifier

R-HSA-2466391

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter

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PRC (PPRC1) binds NRF1 and coactivates genes regulated by NRF1 (Andersson and Scarpulla 2001, Vercauteren et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11340167	Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells Andersson, U, Scarpulla, RC	Mol Cell Biol	2001
18343819	PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression Gleyzer, N, Scarpulla, RC, Vercauteren, K	J Biol Chem	2008

Participants

Input

Output

TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)

Participates

as an event of

Transcriptional activation of mitochondrial biogenesis (Homo sapiens)

Authored

May, B (2011-08-20)

Reviewed

Lezza, AM (2013-12-07)

Created

May, B (2012-09-09)

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