Expression of TFAM

Stable Identifier
R-HSA-1592246
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of TFAM
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The TFAM gene is transcribed in the nucleus to yield mRNA and the mRNA is translated to yield precursor protein in the cytosol.
Literature References
PubMed ID Title Journal Year
10412986 Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Spiegelman, BM, Cinti, S, Lowell, B, Wu, Z, Adelmant, G, Mootha, V, Andersson, U, Zhang, C, Scarpulla, RC, Troy, A, Puigserver, P

Cell 1999
8333869 Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing

Hayashi, J, Tominaga, K, Ohta, S, Kagawa, Y

Biochem Biophys Res Commun 1993
11340167 Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells

Andersson, U, Scarpulla, RC

Mol Cell Biol 2001
8108407 Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis

Virbasius, JV, Scarpulla, RC

Proc Natl Acad Sci U S A 1994
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TFAM gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
Cite Us!