Reactome | SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

Stable Identifier

R-HSA-5688289

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

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Sirtuin 3 (SIRT3) is the most extensively studied of the mitochondrial sirtuins. It deacetylates and thereby activates Acetyl-CoA synthetase 2 (ACCS2), Glutamate dehydrogenase (GLUD), Isocitrate dehydrogenase 2 (IDH2) and Superoxide dismutase 2 (SOD2) (Schwer et al. 2006, Lombard et al. 2007, Schlicker et al. 2008, Tao et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17923681	Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation Murphy, A, Guarente, LP, Kim, J, Alt, FW, Verdin, E, Haigis, M, Bunkenborg, J, Farese, RV, Valenzuela, D, Lombard, DB, Yancopoulos, G, Mostoslavsky, R, Cheng, HL, Yang, Y, Schwer, B, Bronson, RT, Chen, Y, Weissman, S, Hirschey, MD, Streeper, RS	Mol. Cell. Biol.	2007
16788062	Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 Schwer, B, Verdin, RO, Andersen, JS, Verdin, E, Bunkenborg, J	Proc Natl Acad Sci U S A	2006
18680753	Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5 Papatheodorou, P, Schlicker, C, Becker, CF, Steegborn, C, Gertz, M, Kachholz, B	J. Mol. Biol.	2008