SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2

Stable Identifier
Reaction [transition]
Homo sapiens
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Sirtuin 3 (SIRT3) is the most extensively studied of the mitochondrial sirtuins. It deacetylates and thereby activates Acetyl-CoA synthetase 2 (ACCS2), Glutamate dehydrogenase (GLUD), Isocitrate dehydrogenase 2 (IDH2) and Superoxide dismutase 2 (SOD2) (Schwer et al. 2006, Lombard et al. 2007, Schlicker et al. 2008, Tao et al. 2010).

Literature References
PubMed ID Title Journal Year
17923681 Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Murphy, A, Guarente, LP, Kim, J, Alt, FW, Verdin, E, Haigis, M, Bunkenborg, J, Farese, RV, Valenzuela, D, Lombard, DB, Yancopoulos, G, Mostoslavsky, R, Cheng, HL, Yang, Y, Schwer, B, Bronson, RT, Chen, Y, Weissman, S, Hirschey, MD, Streeper, RS

Mol. Cell. Biol. 2007
16788062 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B, Verdin, RO, Andersen, JS, Verdin, E, Bunkenborg, J

Proc Natl Acad Sci U S A 2006
18680753 Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

Papatheodorou, P, Schlicker, C, Becker, CF, Steegborn, C, Gertz, M, Kachholz, B

J. Mol. Biol. 2008
Catalyst Activity

NAD-dependent protein deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]

Orthologous Events
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