Expression of ALAS1

Stable Identifier
R-HSA-1592238
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Expression of 5-aminolevulinate synthase 1
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The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.

Literature References
PubMed ID Title Journal Year
18719978 Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin

Zheng, J, Shan, Y, Lambrecht, RW, Donohue, SE, Bonkovsky, HL

Mol Cell Biochem 2008
11267664 Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes

Roberts, AG, Elder, GH

Biochim Biophys Acta 2001
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