Expression of ALAS1

Stable Identifier
R-HSA-1592238
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
Synonyms
Expression of 5-aminolevulinate synthase 1
ReviewStatus
5/5
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Expression of ALAS1
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The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis. ERR1 (ERRalpha) probably interacts with coactivator PG-1beta to activate ALAS1 (Shao et al. Shao et al. 2010).
Literature References
PubMed ID Title Journal Year
11267664 Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes

Roberts, AG, Elder, GH

Biochim Biophys Acta 2001
18719978 Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin

Bonkovsky, HL, Donohue, SE, Shan, Y, Zheng, J, Lambrecht, RW

Mol Cell Biochem 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
Regulator
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Regulator
ESRRA [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
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