As inferred from mouse, PGC-1alpha (PPARGC1A) activates expression of SIRT3 (Kong et al. 2010).
The SIRT3 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. SIRT3 is imported into the mitochondrial matrix where it deacetylates, and hence activates, target proteins
Cooper, HM, Spelbrink, JN
Barrett, JC, Michishita, E, Horikawa, I, Burneskis, JM, Park, JY
Reinberg, D, Scher, MB, Vaquero, A
Feinberg, AP, Onyango, P, McCaffery, JM, Boeke, JD, Celic, I
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