Expression of ATP5B

Stable Identifier
R-HSA-1592247
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
Synonyms
Expression of ATP Synthase beta subunit
ReviewStatus
5/5
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Expression of ATP5B
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ERR1 (ERRalpha) probably interacts with PGC-1beta to activate expression of ATP5B (Shao et al. 2010).

The ATP5B (ATP synthase beta subunit) gene is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield the ATP5B precursor, which is then imported into the mitochondrial matrix. ATP5B is a peripheral membrane protein located at the matrix face of the inner membrane within the ATP synthase complex (reviewed in Leyva et al. 2003).

Literature References
PubMed ID Title Journal Year
12745923 Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)

Leyva, JA, Bianchet, MA, Amzel, LM

Mol. Membr. Biol. 2003
16890199 Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR

Izquierdo, JM

Biochem Biophys Res Commun 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ESRRA [nucleoplasm] (Homo sapiens)
Regulator
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
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