Expression of GABPA (NRF2 alpha subunit)

Stable Identifier
R-HSA-1592234
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of GABPA (NRF2 alpha subunit)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The GABPA (NRF2 alpha subunit) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Two subunits of GABPA bind two subunits of GABPB1 to form Nuclear respiratory factor 2 (NRF2).

Literature References
PubMed ID Title Journal Year
7799916 Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain

Gugneja, S, Virbasius, JV, Scarpulla, RC

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-PPARGC1A [nucleoplasm] (Homo sapiens)
Regulator
NRF2 [nucleoplasm] (Homo sapiens)
Summation

As inferred from mouse, NRF2 binds the promoter of the GABPA (NRF2 alpha subunit) gene and enhances transcription.

Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
Cite Us!