Expression of PERM1

Stable Identifier
R-HSA-8940309
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of PERM1
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As inferred from the mouse homolog, the PERM1 gene is transcribed to yield mRNA, the mRNA is translated to yield protein. The PERM1 gene is expressed selectively in muscle where it is activated by PPARGC1A via the estrogen receptor ESRRA, which binds regulatory regions of the PERM1 gene. In mouse, Perm1 expression in adult skeletal muscle promotes mitochondrial biogenesis, oxidative capacity and vascularization, without affecting fiber type switching. In mouse, expression of Perm1 is activated by exercise.

Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ESRRA [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Perm1 (Mus musculus)
Authored
May, B  (2016-09-25)
Reviewed
Kralli, A  (2016-11-20)
Created
May, B  (2016-09-26)
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