Expression of POLRMT

Stable Identifier
R-HSA-1592243
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
5/5
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Expression of POLRMT
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The POLRMT (mitochondrial RNA polymerase) gene is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield POLRMT precursor, which is then imported into the mitochondria matrix. In the mitochondrial matrix POLRMT transcribes mitochondrial DNA.
Literature References
PubMed ID Title Journal Year
19951946 Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication

Bruni, F, Polosa, PL, Gadaleta, MN, Cantatore, P, Roberti, M

J Biol Chem 2010
16079853 Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin

Kravchenko, JE, Rogozin, IB, Koonin, EV, Chumakov, PM

Nature 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NRF2 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-08-20)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-09)
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