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Formation of NRF2
Stable Identifier
R-HSA-1592240
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Formation of NRF2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Five subunits (alpha, beta-1, beta-2, gamma-1, gamma-2) assemble to form the DNA-binding transcription factor NRF2 (Gugneja et al. 1995).
Literature References
PubMed ID
Title
Journal
Year
7799916
Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain
Virbasius, JV
,
Gugneja, S
,
Scarpulla, RC
Mol Cell Biol
1995
Participants
Input
GABPA [nucleoplasm]
(Homo sapiens)
NRF2 beta-1 subunit [nucleoplasm]
(Homo sapiens)
NRF2 beta-2 subunit [nucleoplasm]
(Homo sapiens)
NRF2 gamma-1 subunit [nucleoplasm]
(Homo sapiens)
NRF2 gamma-2 subunit [nucleoplasm]
(Homo sapiens)
Output
NRF2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Orthologous Events
Formation of NRF2 (Bos taurus)
Formation of NRF2 (Canis familiaris)
Formation of NRF2 (Danio rerio)
Formation of NRF2 (Drosophila melanogaster)
Formation of NRF2 (Gallus gallus)
Formation of NRF2 (Mus musculus)
Formation of NRF2 (Rattus norvegicus)
Formation of NRF2 (Sus scrofa)
Formation of NRF2 (Xenopus tropicalis)
Authored
May, B (2011-08-20)
Reviewed
Lezza, AM (2013-12-07)
Created
May, B (2011-09-09)
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