SIRT4 transfers ADPRib to GLUD

Stable Identifier
R-HSA-5688276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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SIRT4 transfers ADPRib to GLUD
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Sirtuin 4 (SIRT4) is a mitochondrial ADP-ribosyltransferase and deacetylase. It uses NAD+ to ADP-ribosylate glutamate dehydrogenase (GLUD), reducing its enzyme activity by at least 50%, leading to reduced insulin secretion in pancreatic beta cells (Haigis et al. 2006, Ahuja et al. 2007).

Literature References
PubMed ID Title Journal Year
17715127 Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

Ahuja, N, Schwer, B, Carobbio, S, Waltregny, D, North, BJ, Castronovo, V, Maechler, P, Verdin, E

J. Biol. Chem. 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of SIRT4:Zn2+ [mitochondrial matrix]
Physical Entity
SIRT4:Zn2+ [mitochondrial matrix]
Activity
NAD+ ADP-ribosyltransferase activity (0003950)
Orthologous Events
SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)
SIRT4 transfers ADPRib to GLUD (Canis familiaris)
SIRT4 transfers ADPRib to GLUD (Danio rerio)
SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)
SIRT4 transfers ADPRib to GLUD (Mus musculus)
SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)
SIRT4 transfers ADPRib to GLUD (Sus scrofa)
SIRT4 transfers ADPRib to GLUD (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-15)
Reviewed
Haigis, M  (2017-02-01)
Created
Jupe, S  (2015-04-15)
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