SIRT4 transfers ADPRib to GLUD

Stable Identifier
R-HSA-5688276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Sirtuin 4 (SIRT4) is a mitochondrial ADP-ribosyltransferase and deacetylase. It uses NAD+ to ADP-ribosylate glutamate dehydrogenase (GLUD), reducing its enzyme activity by at least 50%, leading to reduced insulin secretion in pancreatic beta cells (Haigis et al. 2006, Ahuja et al. 2007).
Literature References
PubMed ID Title Journal Year
17715127 Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

Waltregny, D, North, BJ, Maechler, P, Verdin, E, Carobbio, S, Schwer, B, Castronovo, V, Ahuja, N

J. Biol. Chem. 2007
Participants
Participates
Catalyst Activity

NAD+-protein poly-ADP-ribosyltransferase activity of SIRT4:Zn2+ [mitochondrial matrix]

Orthologous Events
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