Sirtuin 4 (SIRT4) is a mitochondrial ADP-ribosyltransferase and deacetylase. It uses NAD+ to ADP-ribosylate glutamate dehydrogenase (GLUD), reducing its enzyme activity by at least 50%, leading to reduced insulin secretion in pancreatic beta cells (Haigis et al. 2006, Ahuja et al. 2007).
Waltregny, D, North, BJ, Maechler, P, Verdin, E, Carobbio, S, Schwer, B, Castronovo, V, Ahuja, N
NAD+ ADP-ribosyltransferase activity of SIRT4:Zn2+ [mitochondrial matrix]
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