SIRT5 deacetylates Cytochrome C

Stable Identifier
R-HSA-5688294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
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SIRT5 deacetylates Cytochrome C
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Sirtuin 5 has been shown to deacetylate Cytochrome C in the the mitochondrial intermembrane space (Schlicker et al. 2008). The functional significance of this is unknown (Bao & Sack 2010).
Literature References
PubMed ID Title Journal Year
18680753 Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

Papatheodorou, P, Schlicker, C, Becker, CF, Steegborn, C, Gertz, M, Kachholz, B

J. Mol. Biol. 2008
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Catalyst Activity

NAD-dependent protein lysine deacetylase activity of SIRT5:Zn2+ [mitochondrial intermembrane space]

Physical Entity
SIRT5:Zn2+ [mitochondrial intermembrane space] (Homo sapiens)
Activity
NAD-dependent protein lysine deacetylase activity (GO:0034979)
Orthologous Events
SIRT5 deacetylates Cytochrome C (Bos taurus)
SIRT5 deacetylates Cytochrome C (Danio rerio)
SIRT5 deacetylates Cytochrome C (Dictyostelium discoideum)
SIRT5 deacetylates Cytochrome C (Gallus gallus)
SIRT5 deacetylates Cytochrome C (Mus musculus)
SIRT5 deacetylates Cytochrome C (Plasmodium falciparum)
SIRT5 deacetylates Cytochrome C (Rattus norvegicus)
SIRT5 deacetylates Cytochrome C (Sus scrofa)
SIRT5 deacetylates Cytochrome C (Xenopus tropicalis)
Authored
Jupe, S  (2015-04-15)
Reviewed
Haigis, M  (2017-02-01)
Created
Jupe, S  (2015-04-15)
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