Sirtuin 5 has been shown to deacetylate Cytochrome C in the the mitochondrial intermembrane space (Schlicker et al. 2008). The functional significance of this is unknown (Bao & Sack 2010).
Papatheodorou, P, Schlicker, C, Becker, CF, Steegborn, C, Gertz, M, Kachholz, B
NAD-dependent protein deacetylase activity of SIRT5:Zn2+ [mitochondrial intermembrane space]
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