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HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-2130442
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
2DRA_HUMAN, HLA-DRA
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
MHC class II alpha/beta dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HLA II alpha chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
MHC class II alpha/beta dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HLA II alpha chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01903 HLA-DRA
Gene Names
HLA-DRA, HLA-DRA1
Chain
signal peptide:1-25, chain:26-254
Reference Genes
BioGPS Gene:3122 HLA-DRA
COSMIC (genes):HLA-DRA HLA-DRA
CTD Gene:3122 HLA-DRA
dbSNP Gene:3122 HLA-DRA
ENSEMBL:ENSG00000204287 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000204287.14 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000206308.11 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000226260.9 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000227993.9 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000228987.9 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000230726.9 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000234794.9 HLA-DRA
ENSEMBL_homo_sapiens_GENE:ENSG00000277263.1 HLA-DRA
HGNC:4947 HLA-DRA
KEGG Gene (Homo sapiens):3122 HLA-DRA
Monarch:3122 HLA-DRA
NCBI Gene:3122 HLA-DRA
OMIM:142860 HLA-DRA
UCSC:P01903 HLA-DRA
Reference Transcript
RefSeq:NM_019111.4 HLA-DRA
Other Identifiers
11742850_x_at
11744484_s_at
11750527_s_at
17007257
17028313
17031139
17033604
17035880
17038596
17041225
208894_PM_at
208894_at
210982_PM_s_at
210982_s_at
2903191
2903192
2903195
2903196
2903197
2903198
2903200
2903202
2903203
2903204
2903205
3122
37039_at
8118548
8178193
8179481
A_32_P87697
GE82473
GO:0000139
GO:0001772
GO:0001916
GO:0002250
GO:0002376
GO:0002469
GO:0002491
GO:0002503
GO:0002504
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0007155
GO:0009986
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030154
GO:0030247
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031901
GO:0031902
GO:0032395
GO:0032588
GO:0032831
GO:0042605
GO:0042608
GO:0042613
GO:0043226
GO:0043382
GO:0045622
GO:0048856
GO:0050778
GO:0050870
GO:0050877
GO:0050890
GO:0060089
GO:0065003
GO:0070062
GO:0098553
GO:0120281
GO:2000516
HMNXSV003039212
ILMN_1689655
ILMN_2157441
PH_hs_0030089
PH_hs_0035922
TC06000399.hg
TC6_cox_hap2000090.hg
TC6_dbb_hap3000083.hg
TC6_mann_hap4000074.hg
TC6_mcf_hap5000075.hg
TC6_qbl_hap6000081.hg
TC6_ssto_hap7000076.hg
X00274_at
g188255_3p_a_at
Participates
as a member of
HLA II alpha chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane]
Inferred To
H2-Ea [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
BoLA-DRA [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
RT1-Da [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
SLA-DRA1 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
DLA-DRA [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
mhc2-daa [clathrin-coated endocytic vesicle membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_061984.2
OpenTargets
ENSG00000204287
GeneCards
P01903
HPA
ENSG00000204287-HLA-DRA
Ensembl
ENSG00000277263
,
ENST00000395388
,
ENSP00000372608
,
ENST00000383127
,
ENSG00000228987
,
ENST00000416883
,
ENSG00000234794
,
ENSP00000378786
,
ENSG00000206308
,
ENSP00000404533
,
ENSP00000402951
,
ENST00000414698
,
ENSP00000479287
,
ENSG00000226260
,
ENSP00000410443
,
ENST00000411524
,
ENSG00000204287
,
ENST00000613328
,
ENSG00000230726
,
ENSP00000372746
,
ENSG00000227993
,
ENST00000442960
,
ENSP00000405295
,
ENST00000383259
PRO
P01903
Pharos - Targets
P01903
Orphanet
16201
PDB
4MCY
,
5NI9
,
4GBX
,
2SEB
,
4AH2
,
4X5X
,
8CMG
,
2Q6W
,
1HXY
,
3PGC
,
4AEN
,
4MD5
,
6BIV
,
1JWM
,
2OJE
,
1T5X
,
1PYW
,
5V4N
,
8CMB
,
1KLU
,
2G9H
,
6BIR
,
7YXB
,
7NZE
,
6V13
,
6CPL
,
6CQN
,
2IAN
,
6BIL
,
8CMH
,
6QZA
,
2FSE
,
3PGD
,
4MD4
,
6BIZ
,
6ATF
,
4C56
,
4FQX
,
6BIX
,
1J8H
,
1A6A
,
4X5W
,
4Y1A
,
6NIX
,
3PDO
,
6CPN
,
1R5I
,
7Z0Q
,
1KG0
,
3QXD
,
1HQR
,
1D5X
,
3S4S
,
8CMC
,
3C5J
,
8EUQ
,
4H1L
,
6CQQ
,
1LO5
,
5V4M
,
6V15
,
6BIN
,
4MD0
,
6QZC
,
2IPK
,
6CQJ
,
8CMI
,
1SJE
,
1YMM
,
4OV5
,
8CME
,
3T0E
,
6R0E
,
1D5M
,
4IS6
,
6BIY
,
6CPO
,
6V18
,
1JWS
,
6CQR
,
3O6F
,
5LAX
,
1AQD
,
8CMD
,
2XN9
,
3L6F
,
4MDJ
,
7YX9
,
6ATI
,
2WBJ
,
4I5B
,
3S5L
,
8TBP
,
1D6E
,
1FV1
,
1SJH
,
4H26
,
6QZD
,
1ZGL
,
6CQL
,
7N19
,
6BIJ
,
4H25
,
2ICW
,
1KLG
,
3QXA
,
6ATZ
,
1SEB
,
1H15
,
4MCZ
,
1T5W
,
1FYT
,
6V1A
,
8CMF
,
1D5Z
,
6V19
,
2IAM
,
1BX2
,
4MDI
,
4E41
,
1DLH
,
5JLZ
,
7O00
,
4Y19
,
6V0Y
,
5NIG
,
1JWU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04233 CD74
13
CD74(81-104) [lysosomal lumen]
(R-HSA-2213220)
CD74(81-104) [lysosomal membrane]
(R-HSA-2130446)
CD74(1-117) [lysosomal membrane]
(R-HSA-2130632)
CD74 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-1181241)
CD74 [ER to Golgi transport vesicle membrane]
(R-HSA-2130456)
CD74 [Golgi membrane]
(R-HSA-2214388)
CD74 [trans-Golgi network membrane]
(R-HSA-2130493)
CD74 [transport vesicle membrane]
(R-HSA-2130624)
CD74 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130522)
CD74 [endocytic vesicle membrane]
(R-HSA-2130460)
CD74(1-176) [lysosomal membrane]
(R-HSA-2130602)
CD74 [lysosomal membrane]
(R-HSA-2130320)
CD74 [plasma membrane]
(R-HSA-2130666)
0.564
2
UniProt:Q9NZJ5 EIF2AK3
3
EIF2AK3 [endoplasmic reticulum membrane]
(R-HSA-381046)
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713456)
EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713454)
0.527
2
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