Reactome | HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [lysosomal membrane]

Stable Identifier

R-HSA-2130677

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

2DRA_HUMAN, HLA-DRA

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01903 HLA-DRA

Gene Names

HLA-DRA, HLA-DRA1

Chain

signal peptide:1-25, chain:26-254

Reference Genes

BioGPS Gene:3122 HLA-DRA

COSMIC (genes):HLA-DRA HLA-DRA

CTD Gene:3122 HLA-DRA

dbSNP Gene:3122 HLA-DRA

ENSEMBL:ENSG00000204287 HLA-DRA

HGNC:4947 HLA-DRA

KEGG:hsa:3122 HLA-DRA

Monarch:3122 HLA-DRA

NCBI Gene:3122 HLA-DRA

OMIM:142860 HLA-DRA

UCSC:P01903 HLA-DRA

Reference Transcript

RefSeq:NM_019111.4 HLA-DRA

Other Identifiers

11742850_x_at

11744484_s_at

11750527_s_at

17007257

17028313

17031139

17033604

17035880

17038596

17041225

208894_PM_at

208894_at

210982_PM_s_at

210982_s_at

2903191

2903192

2903195

2903196

2903197

2903198

2903200

2903202

2903203

2903204

2903205

3122

37039_at

8118548

8178193

8179481

A_32_P87697

GE82473

GE88126

GO:0000139

GO:0001772

GO:0001916

GO:0002250

GO:0002376

GO:0002469

GO:0002491

GO:0002503

GO:0002504

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005886

GO:0006955

GO:0009986

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030247

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0031901

GO:0031902

GO:0032395

GO:0032588

GO:0032831

GO:0042605

GO:0042608

GO:0042613

GO:0043226

GO:0043382

GO:0045622

GO:0050778

GO:0050870

GO:0050877

GO:0050890

GO:0060089

GO:0065003

GO:0070062

GO:0098553

GO:0120281

GO:2000516

HMNXSV003039212

ILMN_1689655

ILMN_2157441

PH_hs_0030089

PH_hs_0035922

TC06000399.hg

TC6_cox_hap2000090.hg

TC6_dbb_hap3000083.hg

TC6_mann_hap4000074.hg

TC6_mcf_hap5000075.hg

TC6_qbl_hap6000081.hg

TC6_ssto_hap7000076.hg

X00274_at

g188255_3p_a_at

Participates

as a member of

HLA II alpha chain [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [transport vesicle membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DR alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

Inferred To

mhc2-daa [lysosomal membrane] (Xenopus tropicalis)

SLA-DRA1 [lysosomal membrane] (Sus scrofa)

H2-Ea [lysosomal membrane] (Mus musculus)

DLA-DRA [lysosomal membrane] (Canis familiaris)

BoLA-DRA [lysosomal membrane] (Bos taurus)

RT1-Da [lysosomal membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_061984.2

OpenTargets

ENSG00000204287

ENSEMBL

ENSP00000378786, ENSP00000405295, ENST00000416883, ENST00000383127, ENSP00000410443, ENST00000383259, ENST00000613328, ENST00000442960, ENSP00000479287, ENSP00000404533, ENSP00000402951, ENSP00000372746, ENST00000411524, ENSP00000372608, ENST00000395388, ENST00000414698

HPA

ENSG00000204287-HLA-DRA

PRO

P01903

Pharos - Targets

P01903

Orphanet

HLA-DRA

PDB

4MCZ, 4MD0, 1T5X, 6QZA, 1ZGL, 4H26, 4H1L, 2WBJ, 4C56, 1H15, 5V4M, 8CMC, 3T0E, 4X5W, 6BIV, 6BIJ, 6BIY, 1YMM, 4MD5, 1KLU, 1A6A, 1D5X, 1SJH, 6ATI, 1D5M, 1R5I, 6V1A, 8CMD, 6V18, 2ICW, 6CQN, 2IPK, 3S5L, 1KG0, 1HXY, 1T5W, 2IAN, 6QZD, 4MCY, 4H25, 8PJF, 6BIN, 7Z0Q, 8CME, 3O6F, 7YXB, 6BIL, 6BIX, 8CMH, 6BIR, 3QXA, 1JWS, 5NI9, 6V0Y, 6V15, 3C5J, 4Y19, 7N19, 6CQQ, 4AH2, 2SEB, 4FQX, 1FV1, 4I5B, 2G9H, 1DLH, 6QZC, 2IAM, 3S4S, 4MDI, 3PGD, 8TBP, 5NIG, 8VRW, 2OJE, 2FSE, 6R0E, 7O00, 1JWM, 4X5X, 8CMI, 3PDO, 4AEN, 8CMG, 4OV5, 1D6E, 1KLG, 6ATZ, 6CPL, 4GBX, 1SEB, 6CPO, 4Y1A, 3PGC, 1J8H, 1FYT, 6CQR, 3L6F, 5JLZ, 1AQD, 6ATF, 4E41, 8PJE, 1HQR, 8PJG, 1PYW, 5V4N, 4MDJ, 6CQL, 7YX9, 3QXD, 8CMB, 8EUQ, 1BX2, 8CMF, 6BIZ, 4MD4, 1JWU, 1SJE, 1LO5, 6V13, 6V19, 4IS6, 6CPN, 6NIX, 7NZE, 6CQJ, 2XN9, 5LAX, 1D5Z, 2Q6W

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.564	2
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.527	2

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