Reactome | CD44 [secretory granule membrane]

CD44 [secretory granule membrane]

Stable Identifier

R-HSA-6804776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule membrane

Synonyms

CD44 antigen, CD44_HUMAN, Hyaluronate receptor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P16070 CD44

Gene Names

CD44, LHR, MDU2, MDU3, MIC4

Chain

signal peptide:1-20, chain:21-742

Reference Genes

BioGPS Gene:960 CD44

COSMIC (genes):CD44 CD44

CTD Gene:960 CD44

dbSNP Gene:960 CD44

ENSEMBL:ENSG00000026508 CD44

ENSEMBL_homo_sapiens_GENE:ENSG00000026508.21 CD44

HGNC:1681 CD44

KEGG Gene (Homo sapiens):960 CD44

Monarch:960 CD44

NCBI Gene:960 CD44

OMIM:107269 CD44

UCSC:P16070 CD44

Reference Transcript

Other Identifiers

1125_s_at

1126_s_at

11715915_a_at

11715916_a_at

11715917_a_at

11739617_x_at

11742043_a_at

11744654_s_at

11750189_s_at

11750190_x_at

11753291_a_at

11753292_x_at

1557905_3p_s_at

1557905_PM_s_at

1557905_s_at

16723614

2036_s_at

204489_PM_s_at

204489_s_at

204490_PM_s_at

204490_s_at

209835_PM_x_at

209835_x_at

210916_PM_s_at

210916_s_at

212014_PM_x_at

212014_x_at

212063_PM_at

212063_at

31472_s_at

3326636

3326637

3326652

3326653

3326658

3326664

3326666

3326667

3326668

3326669

3326683

3326686

3326694

3326696

3326700

3326705

3326711

3326712

3326714

3326717

3326720

3326721

3326722

3326726

3326727

3326728

3326729

40493_at

7939341

960

A_14_P108079

A_14_P114193

A_23_P24870

A_33_P3294509

GE59805

GE80929

GO:0002376

GO:0004888

GO:0004896

GO:0005515

GO:0005518

GO:0005540

GO:0005576

GO:0005615

GO:0005794

GO:0005829

GO:0005886

GO:0005902

GO:0005925

GO:0006954

GO:0007155

GO:0007160

GO:0009986

GO:0012501

GO:0016020

GO:0016323

GO:0016324

GO:0016477

GO:0019221

GO:0023052

GO:0030214

GO:0030667

GO:0031258

GO:0031410

GO:0033138

GO:0034116

GO:0035692

GO:0036211

GO:0042060

GO:0042110

GO:0042995

GO:0043066

GO:0043154

GO:0043226

GO:0043518

GO:0044319

GO:0044344

GO:0048856

GO:0048870

GO:0050731

GO:0051216

GO:0060089

GO:0070062

GO:0070374

GO:0070487

GO:0098609

GO:1900625

GO:1901135

GO:1902166

GO:2000392

HMNXSV003013394

HMNXSV003035204

HMNXSV003053350

Hs.323950.2.A1_3p_at

Hs2.423212.1.S1_3p_s_at

ILMN_1778625

ILMN_1803429

ILMN_2348788

PH_hs_0032595

TC11000332.hg

g10835162_3p_a_at

g13325117_3p_a_at

g180196_3p_s_at

Participates

as a member of

Secretory granule membrane proteins [secretory granule membrane] (Homo sapiens)

Other forms of this molecule

CD44 [plasma membrane]

Inferred To

CD44 [secretory granule membrane] (Bos taurus)

CD44 [secretory granule membrane] (Canis familiaris)

CD44 [secretory granule membrane] (Gallus gallus)

CD44 [secretory granule membrane] (Mus musculus)

CD44 [secretory granule membrane] (Rattus norvegicus)

CD44 [secretory granule membrane] (Sus scrofa)

Cross References

RefSeq

NP_001001389.1, NP_001001391.1, NP_001189485.1, NP_001189486.1, NP_000601.3, XP_011518790.1, NP_001189484.1, NP_001001392.1, NP_001001390.1

OpenTargets

ENSG00000026508

HPA

ENSG00000026508-CD44

GeneCards

P16070

Ensembl

ENSG00000026508, ENSP00000392331, ENST00000434472, ENST00000428726, ENST00000415148, ENSP00000309732, ENST00000263398, ENST00000352818, ENST00000278386, ENSP00000398632, ENST00000433892, ENSP00000263398, ENSP00000389830, ENSP00000404447, ENSP00000278386

ZINC target

P16070

PRO

P16070

Pharos - Targets

P16070

HMDB Protein

HMDBP01716

PDB

4PZ3, 6TXS, 1POZ, 4PZ4, 2I83, 1UUH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18011 SCTE			0.632	4
ChEBI:61048 GANGLIOSIDE			0.556	3
hyaluronic acid [ChEBI:16336]	3	HUA [endocytic vesicle lumen] (R-ALL-2239419) HUA [extracellular region] (R-ALL-1297302) HUA [cytosol] (R-ALL-877209)	0.544	2
UniProt:Q9UPY5 SLC7A11	1	SLC7A11 [plasma membrane] (R-HSA-378515)	0.537	4
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.527	2
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	3
UniProt:P10451 SPP1	5	SPP1 [extracellular region] (R-HSA-215967) SPP1 [endoplasmic reticulum lumen] (R-HSA-8956713) p-SPP1 [endoplasmic reticulum lumen] (R-HSA-8956883) SPP1(17-?) [extracellular region] (R-HSA-4093351) SPP1(?-314) [extracellular region] (R-HSA-4093349)	0.507	4
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.463	6
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.463	9
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	3

Cite Us!