Reactome | HLA class II histocompatibility antigen, DQ [plasma membrane]

HLA class II histocompatibility antigen, DQ [plasma membrane]

Stable Identifier

R-HSA-197585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HA23_HUMAN, HLA-DQA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01909 HLA-DQA1

Gene Names

HLA-DQA1

Chain

signal peptide:1-23, chain:24-254

Reference Genes

BioGPS Gene:3117 HLA-DQA1

COSMIC (genes):HLA-DQA1 HLA-DQA1

CTD Gene:3117 HLA-DQA1

dbSNP Gene:3117 HLA-DQA1

ENSEMBL:ENSG00000196735 HLA-DQA1

HGNC:4942 HLA-DQA1

KEGG:hsa:3117 HLA-DQA1

Monarch:3117 HLA-DQA1

NCBI Gene:3117 HLA-DQA1

OMIM:146880 HLA-DQA1

UCSC:P01909 HLA-DQA1

Reference Transcript

RefSeq:NM_002122.3 HLA-DQA1

Other Identifiers

11724799_x_at

11750528_x_at

11753898_x_at

11756083_x_at

11758340_x_at

17007266

17028326

17038609

17041240

203290_PM_at

203290_at

212671_PM_s_at

212671_s_at

213831_PM_at

213831_at

236203_PM_at

236203_at

2903223

2903224

2903227

2903229

2903231

2903233

2903234

2903235

2903236

2903259

2903265

2903266

3117

32773_at

8118556

81488_at

8178199

8179489

A_23_P30900

A_24_P196827

A_24_P326084

A_24_P393230

A_33_P3293049

GE81121

GE863920

GE890404

GO:0000139

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0031902

GO:0032395

GO:0032588

GO:0042605

GO:0042613

GO:0043226

GO:0046872

GO:0050778

GO:0050870

GO:0060089

GO:0065003

GO:0098553

HMNXSV003000947

HMNXSV003054155

HMNXSV003055601

HMNXSV003056103

Hs.120695.0.A1_3p_at

Hs.198253.1.A1_3p_a_at

Hs.198253.2.A1_3p_s_at

ILMN_1808405

K01160_s_at

M26041_s_at

M34996_s_at

PH_hs_0033085

TC06000400.hg

TC6_cox_hap2000091.hg

TC6_qbl_hap6000082.hg

TC6_ssto_hap7000077.hg

g4504406_3p_at

p26545

p26546

Participates

as a member of

HLA II alpha chain [plasma membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DQ [lysosomal membrane]

HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DQ [transport vesicle membrane]

HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DQ [Golgi membrane]

HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane]

Inferred To

H2-Aa [plasma membrane] (Mus musculus)

si:busm1-194e12.8 [plasma membrane] (Danio rerio)

DLA-DQA1 [plasma membrane] (Canis familiaris)

mhc2d8.45b1 [plasma membrane] (Danio rerio)

mhc2-daa [plasma membrane] (Xenopus tropicalis)

hla-dpa1 [plasma membrane] (Danio rerio)

mhc2daa [plasma membrane] (Danio rerio)

SLA-DQA1 [plasma membrane] (Sus scrofa)

BOLA-DQA1 [plasma membrane] (Bos taurus)

HLA class II histocompatibility antigen, DQ [plasma membrane] (Sus scrofa)

mhc2dgb [plasma membrane] (Danio rerio)

RT1-Ba [plasma membrane] (Rattus norvegicus)

Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane] (Danio rerio)

Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_002113.2

OpenTargets

ENSG00000196735

ENSEMBL

ENSP00000378767, ENSP00000413237, ENST00000399675, ENSP00000382586, ENSG00000206305, ENSG00000196735, ENST00000383251, ENSP00000339398, ENSP00000387892, ENSP00000372738, ENST00000343139, ENST00000444296, ENST00000418023, ENST00000374949, ENSP00000382583, ENST00000399678, ENSG00000232062, ENST00000395363, ENSP00000364087

HPA

ENSG00000196735-HLA-DQA1

GeneCards

HLA-DQA1

PRO

P01909

Pharos - Targets

P01909

Orphanet

HLA-DQA1

PDB

1UVQ, 4GG6, 8W85, 8W86, 5KSU, 2NNA, 6U3M, 6MFG, 8W83, 6MFF, 6U3N, 8W84, 7SG1, 6XP6, 7SG0, 7SG2, 1S9V, 1JK8, 5KSV, 8VSP, 5KSB, 5KSA, 4OZH, 4OZG, 4OZF, 4OZI

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04233 CD74	13	CD74 [plasma membrane] (R-HSA-2130666) CD74 [lysosomal membrane] (R-HSA-2130320) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220)	0.674	4
UniProt:O43612 HCRT	2	HCRT(70-97) [extracellular region] (R-HSA-389473) HCRT(34-66) [extracellular region] (R-HSA-389500)	0.564	2

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