Reactome | HLA class II histocompatibility antigen, DP [lysosomal membrane]

HLA class II histocompatibility antigen, DP [lysosomal membrane]

Stable Identifier

R-HSA-2130601

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

HB2P_HUMAN, HLA-DPB1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04440 HLA-DPB1

Gene Names

HLA-DPB1, HLA-DP1B

Chain

signal peptide:1-29, chain:30-258

Reference Genes

BioGPS Gene:3115 HLA-DPB1

COSMIC (genes):HLA-DPB1 HLA-DPB1

CTD Gene:3115 HLA-DPB1

dbSNP Gene:3115 HLA-DPB1

ENSEMBL:ENSG00000223865 HLA-DPB1

HGNC:4940 HLA-DPB1

KEGG:hsa:3115 HLA-DPB1

Monarch:3115 HLA-DPB1

NCBI Gene:3115 HLA-DPB1

OMIM:142858 HLA-DPB1

UCSC:P04440 HLA-DPB1

Reference Transcript

RefSeq:NM_002121.5 HLA-DPB1

Other Identifiers

11717299_at

11717300_x_at

11755279_x_at

11756073_x_at

11757801_x_at

11758369_x_at

11759666_x_at

11761306_at

11761307_x_at

17007352

17026444

17031219

17033704

17035971

17038687

17041318

201137_PM_s_at

201137_s_at

2903402

2903403

2903411

2903412

2903413

2903414

2903415

2903416

2903417

2903418

2903419

2903420

2903421

2903422

2903423

2903424

2903425

2903426

2903428

2903429

2903430

2903431

2903432

2903433

2903434

3115

38095_i_at

38096_f_at

66616_at

8118594

8178220

8179519

A_14_P132932

A_23_P258769

A_24_P166443

A_33_P3271634

A_33_P3271635

A_33_P3271651

GE61021

GE81120

GE906236

GO:0000139

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0009986

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0031902

GO:0032588

GO:0032729

GO:0042102

GO:0042605

GO:0042613

GO:0043226

GO:0050778

GO:0050852

GO:0050870

GO:0065003

GO:0098553

HMNXSV003013571

HMNXSV003024464

ILMN_1749070

M57466_s_at

M83664_at

PH_hs_0024067

Participates

as a member of

HLA II beta chain [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DP [plasma membrane]

HLA class II histocompatibility antigen, DP [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP [transport vesicle membrane]

HLA class II histocompatibility antigen, DP [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DP [Golgi membrane]

HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane]

Inferred To

HLA class II histocompatibility antigen, DP [lysosomal membrane] (Canis familiaris)

b2m [lysosomal membrane] (Danio rerio)

mhc2-dab [lysosomal membrane] (Xenopus tropicalis)

zmp:0000001138 [lysosomal membrane] (Danio rerio)

Homologues of HLA class II histocompatibility antigen, DP [lysosomal membrane] (Danio rerio)

RT1-Hb-ps1 [lysosomal membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002112.3

OpenTargets

ENSG00000223865

ENSEMBL

ENST00000433800, ENSP00000396095, ENST00000454006, ENSP00000407674, ENSP00000414196, ENST00000399500, ENST00000418931, ENSP00000382422, ENSP00000389288, ENSP00000408146, ENST00000411749, ENST00000425130

HPA

ENSG00000223865-HLA-DPB1

PRO

P04440

Pharos - Targets

P04440

Orphanet

HLA-DPB1

PDB

7T2D, 7T2A, 4P5M, 7T2B, 4P57, 7T2C, 4P4K, 4P4R, 4P5K, 3LQZ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.527	2