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CXCR4 [plasma membrane]
Stable Identifier
R-HSA-2980772
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-X-C chemokine receptor type 4, CXCR4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
SLIT2:ROBO1 binds CXCR4 (Homo sapiens)
CXCL12:CXCR4:ROBO1:SLIT2 [plasma membrane] (Homo sapiens)
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Conformational changes in gp120 exposes gp41 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Fusion of viral membrane with host cell membrane (Homo sapiens)
CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Fusogenic activation of gp41 (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
CXCR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61073 CXCR4
Gene Names
CXCR4
Chain
chain:1-352
Reference Genes
BioGPS Gene:7852 CXCR4
COSMIC (genes):CXCR4 CXCR4
CTD Gene:7852 CXCR4
dbSNP Gene:7852 CXCR4
ENSEMBL:ENSG00000121966.8 CXCR4
HGNC:2561 CXCR4
KEGG Gene (Homo sapiens):7852 CXCR4
Monarch:7852 CXCR4
NCBI Gene:7852 CXCR4
OMIM:162643 CXCR4
UCSC:P61073 CXCR4
Reference Transcript
RefSeq:NM_001348059.1 CXCR4
RefSeq:NM_003467.2 CXCR4
RefSeq:NM_001348060.1 CXCR4
RefSeq:NM_001348056.1 CXCR4
RefSeq:NM_001008540.2 CXCR4
Other Identifiers
0002340593
11728189_a_at
11728190_s_at
11728191_x_at
11739094_a_at
16903140
209201_3p_x_at
209201_PM_x_at
209201_x_at
211919_PM_s_at
211919_s_at
217028_PM_at
217028_at
2578041
2578042
2578043
2578044
2578045
2578046
2578047
2578052
649_s_at
7852
8055465
A_23_P102000
GE54062
GO:0001618
GO:0001666
GO:0001764
GO:0002064
GO:0002376
GO:0002407
GO:0003012
GO:0003013
GO:0003779
GO:0004930
GO:0004950
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005829
GO:0005886
GO:0006915
GO:0006935
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007186
GO:0007204
GO:0007420
GO:0008038
GO:0008092
GO:0009615
GO:0009897
GO:0009986
GO:0012501
GO:0014070
GO:0014823
GO:0015026
GO:0016020
GO:0016021
GO:0016477
GO:0016493
GO:0016494
GO:0019722
GO:0019955
GO:0019957
GO:0022008
GO:0022029
GO:0023052
GO:0030154
GO:0030155
GO:0030312
GO:0030335
GO:0031012
GO:0031252
GO:0031410
GO:0031625
GO:0032027
GO:0032991
GO:0035470
GO:0036094
GO:0038147
GO:0038160
GO:0042060
GO:0043067
GO:0043130
GO:0043217
GO:0043226
GO:0043278
GO:0045446
GO:0046718
GO:0048714
GO:0048856
GO:0048870
GO:0050769
GO:0050792
GO:0050877
GO:0050920
GO:0050921
GO:0050965
GO:0050966
GO:0051924
GO:0055065
GO:0060048
GO:0060089
GO:0060326
GO:0061024
GO:0061154
GO:0070062
GO:0070098
GO:0070161
GO:0071345
GO:0071417
GO:0071466
GO:0120162
GO:1901327
GO:1903861
GO:1905322
GO:1990478
GO:2000448
HMNXSV003031179
Hs.89414.1.S1_3p_at
ILMN_1683307
ILMN_1728937
ILMN_1801584
ILMN_2246410
ILMN_2320888
L06797_s_at
PH_hs_0019757
TC02002378.hg
g13549089_3p_s_at
g189313_3p_a_at
Participates
as a member of
CCR5, CXCR4 [plasma membrane] (Homo sapiens)
CXCR4,7 [plasma membrane] (Homo sapiens)
as a component of
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
Inferred To
npr-32 [plasma membrane]
(Caenorhabditis elegans)
Homologues of CXCR4 [plasma membrane]
(Canis familiaris)
cxcr4 [plasma membrane]
(Xenopus tropicalis)
CXCR4 [plasma membrane]
(Bos taurus)
CXCR4 [plasma membrane]
(Canis familiaris)
CXCR4 [plasma membrane]
(Danio rerio)
CXCR4 [plasma membrane]
(Gallus gallus)
CXCR4 [plasma membrane]
(Sus scrofa)
Cxcr4 [plasma membrane]
(Mus musculus)
Cxcr4 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001334988.1
,
NP_001334989.1
,
NP_001334985.1
,
NP_003458.1
,
NP_001008540.1
ZINC - World Drugs
CXCR4_HUMAN
Guide to Pharmacology - Targets
71
OpenTargets
ENSG00000121966
ZINC - FDA approved
CXCR4_HUMAN
ZINC - Substances
CXCR4_HUMAN
ZINC target
P61073
PRO
P61073
PDB
3OE9
,
2K04
,
4RWS
,
2K03
,
3OE0
,
3OE6
,
2K05
,
2N55
,
3ODU
,
3OE8
ZINC - Investigational
CXCR4_HUMAN
GeneCards
P61073
HPA
ENSG00000121966-CXCR4
Ensembl
ENSP00000241393
,
ENST00000241393
,
ENSP00000386884
,
ENSG00000121966
,
ENST00000409817
Pharos - Targets
P61073
Orphanet
15827
ZINC - Predictions - Purchasable
CXCR4_HUMAN
HMDB Protein
HMDBP07643
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-9637646)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-167992)
0.59
3
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.556
5
UniProt:P04233 CD74
13
CD74(81-104) [lysosomal lumen]
(R-HSA-2213220)
CD74(81-104) [lysosomal membrane]
(R-HSA-2130446)
CD74(1-117) [lysosomal membrane]
(R-HSA-2130632)
CD74 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-1181241)
CD74 [ER to Golgi transport vesicle membrane]
(R-HSA-2130456)
CD74 [Golgi membrane]
(R-HSA-2214388)
CD74 [trans-Golgi network membrane]
(R-HSA-2130493)
CD74 [transport vesicle membrane]
(R-HSA-2130624)
CD74 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130522)
CD74 [endocytic vesicle membrane]
(R-HSA-2130460)
CD74(1-176) [lysosomal membrane]
(R-HSA-2130602)
CD74 [lysosomal membrane]
(R-HSA-2130320)
CD74 [plasma membrane]
(R-HSA-2130666)
0.556
4
UniProt:P49682 CXCR3
1
CXCR3 [plasma membrane]
(R-HSA-2980699)
0.512
5
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