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HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
Stable Identifier
R-HSA-2130709
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
integral component of lumenal side of endoplasmic reticulum membrane
Synonyms
HB2P_HUMAN, HLA-DPB1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Dissociation of CANX from nonameric complex (Homo sapiens)
2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
alpha beta dimer:Ii trimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Formation of COPII vesicle (Homo sapiens)
Nonameric complex [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Formation of MHC II alpha beta heterodimer (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Formation of nonameric complex (Homo sapiens)
2xMHC II alpha beta heterodimer:alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
alpha beta dimer:Ii trimer:calnexin [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
MHC II alpha beta heterodimer [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04440 HLA-DPB1
Gene Names
HLA-DPB1, HLA-DP1B
Chain
signal peptide:1-29, chain:30-258
Reference Genes
BioGPS Gene:3115 HLA-DPB1
COSMIC (genes):HLA-DPB1 HLA-DPB1
CTD Gene:3115 HLA-DPB1
dbSNP Gene:3115 HLA-DPB1
ENSEMBL:ENSG00000215048.13 HLA-DPB1
ENSEMBL:ENSG00000223865 HLA-DPB1
ENSEMBL:ENSG00000223865.11 HLA-DPB1
ENSEMBL:ENSG00000226826.10 HLA-DPB1
ENSEMBL:ENSG00000230763.11 HLA-DPB1
ENSEMBL:ENSG00000236693.11 HLA-DPB1
ENSEMBL:ENSG00000237710.10 HLA-DPB1
HGNC:4940 HLA-DPB1
KEGG Gene (Homo sapiens):3115 HLA-DPB1
Monarch:3115 HLA-DPB1
NCBI Gene:3115 HLA-DPB1
OMIM:142858 HLA-DPB1
UCSC:P04440 HLA-DPB1
Reference Transcript
RefSeq:NM_002121.5 HLA-DPB1
Other Identifiers
11717299_at
11717300_x_at
11755279_x_at
11756073_x_at
11757801_x_at
11758369_x_at
11759666_x_at
17007352
17026444
17031219
17033704
17035971
17038687
17041318
201137_PM_s_at
201137_s_at
2903402
2903403
2903413
2903414
2903415
2903422
2903423
2903425
2903428
2903429
2903430
2903431
2903432
2903433
2903434
3115
38095_i_at
38096_f_at
66616_at
8118594
8178220
8179519
A_23_P258769
A_24_P166443
A_33_P3271635
A_33_P3271651
GE61021
GE81120
GE906236
GO:0000139
GO:0002250
GO:0002376
GO:0002503
GO:0002504
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0007155
GO:0009986
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0023052
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0032588
GO:0032729
GO:0042102
GO:0042605
GO:0042613
GO:0043226
GO:0050852
GO:0050870
GO:0065003
GO:0098553
HMNXSV003024464
ILMN_1749070
M57466_s_at
M83664_at
PH_hs_0024067
Participates
as a member of
HLA II beta chain [integral component of lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DP [Golgi membrane]
HLA class II histocompatibility antigen, DP [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DP [transport vesicle membrane]
HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DP [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DP [lysosomal membrane]
HLA class II histocompatibility antigen, DP [plasma membrane]
Inferred To
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
(Canis familiaris)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
si:busm1-104n07.3 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
LOC103911540 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
BLB2 [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
hla-drb1 [integral component of lumenal side of endoplasmic reticulum membrane]
(Xenopus tropicalis)
si:ch73-158p21.3 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
si:busm1-228j01.6 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
si:zfos-2070c2.3 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
BLB1 [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
Homologues of HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DP [integral component of lumenal side of endoplasmic reticulum membrane]
(Gallus gallus)
si:busm1-160c18.3 [integral component of lumenal side of endoplasmic reticulum membrane]
(Danio rerio)
Cross References
RefSeq
NP_002112.3
OpenTargets
ENSG00000223865
GeneCards
P04440
HPA
ENSG00000223865-HLA-DPB1
Ensembl
ENSP00000396095
,
ENSP00000408146
,
ENSP00000407674
,
ENSP00000389288
,
ENSG00000215048
,
ENST00000433800
,
ENSG00000223865
,
ENST00000411749
,
ENST00000399500
,
ENSG00000236693
,
ENST00000425130
,
ENSP00000414196
,
ENSG00000237710
,
ENSP00000382422
,
ENSG00000230763
,
ENST00000454006
,
ENST00000418931
,
ENSG00000226826
PRO
P04440
Pharos - Targets
P04440
Orphanet
22272
PDB
7T2A
,
4P5K
,
7T2B
,
7T2C
,
7T2D
,
4P4K
,
4P5M
,
3LQZ
,
4P57
,
4P4R
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
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