Reactome | Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

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Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi Show undefined attributes

authored	[InstanceEdit:745612] Jupe, S, 2010-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:749449] Jupe, S, 2010-05-18
dbId	749456
displayName	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
edited	[InstanceEdit:813668] Jupe, S, 2010-05-26
eventOf	[Pathway:R-HSA-418594] G alpha (i) signalling events - Homo sapiens
followingEvent	[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Homo sapiens
input	[Complex:R-HSA-392165] Heterotrimeric G-protein Gi (inactive) [plasma membrane] [DefinedSet:R-HSA-380091] Ligand:GPCR complexes that activate Gi [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380065] Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
orthologousEvent	[Reaction:R-CEL-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Caenorhabditis elegans [Reaction:R-GGA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Gallus gallus [Reaction:R-BTA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Bos taurus [Reaction:R-CFA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Canis familiaris [Reaction:R-MMU-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Mus musculus
output	[Complex:R-HSA-749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane]
precedingEvent	[Reaction:R-HSA-374173] AGT(25-32) binds to AGTR1 - Homo sapiens [Reaction:R-HSA-9615348] AGT(25-32) binds to AGTR2 - Homo sapiens [Reaction:R-HSA-374337] Apelin receptor binds to apelin - Homo sapiens [Reaction:R-HSA-374331] Bradykinin receptors B1 and B2 bind to bradykinin - Homo sapiens [Reaction:R-HSA-444647] C3a receptor binds anaphylatoxin C3a - Homo sapiens [Reaction:R-HSA-375395] C5a receptor binds C5a anaphylatoxin - Homo sapiens [Reaction:R-HSA-374207] G protein-coupled estrogen receptor 1 binds estrogen non-classically - Homo sapiens [Reaction:R-HSA-374787] GPCR neuropeptide receptor binds neuropeptides B and W - Homo sapiens [Reaction:R-HSA-374723] Nociceptin receptor binds to nociceptin - Homo sapiens [Reaction:R-HSA-374298] Opioid receptors bind opioid peptides - Homo sapiens [Reaction:R-HSA-444523] CXCR5 binds CXCL13 - Homo sapiens [Reaction:R-HSA-373791] Receptor CXCR1 binds CXCL6 and CXCL8 ligands - Homo sapiens [Reaction:R-HSA-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Homo sapiens [Reaction:R-HSA-374248] Receptor CXCR3 binds ligands CXCL9 to 11 - Homo sapiens [Reaction:R-HSA-373358] Receptor CXCR6 binds CXCL16 ligand - Homo sapiens [Reaction:R-HSA-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Homo sapiens [Reaction:R-HSA-373086] Receptor CCR10 binds CCL27 and 28 ligands - Homo sapiens [Reaction:R-HSA-373087] Receptor CCR6 binds CCL20 ligand - Homo sapiens [Reaction:R-HSA-373071] Receptor CCR7 binds CCL19 and 21 ligands - Homo sapiens [Reaction:R-HSA-373074] Receptor CCR9 binds CCL25 ligand - Homo sapiens [Reaction:R-HSA-373073] Receptors CCR1, 2 and 8 bind CCL16 ligand - Homo sapiens [Reaction:R-HSA-373061] Receptors CCR3, 4 and 5 bind CCL5 ligand - Homo sapiens [Reaction:R-HSA-390929] HTR1 and 5A receptors can bind serotonin - Homo sapiens [Reaction:R-HSA-418904] A1 and A3 receptors bind adenosine - Homo sapiens [Reaction:R-HSA-419426] Cannabinoid receptors can bind cannabinoids - Homo sapiens [Reaction:R-HSA-390846] D2D3,4 bind to DA - Homo sapiens [Reaction:R-HSA-390886] HRH4 binds Hist - Homo sapiens [Reaction:R-HSA-390673] CHRM2,4 bind acetylcholine - Homo sapiens [Reaction:R-HSA-417829] P2RY12 binds ADP - Homo sapiens [Reaction:R-HSA-417843] P2Y13 binds ADP - Homo sapiens [Reaction:R-HSA-417858] P2Y14 receptor can bind to UDP-glucose - Homo sapiens [Reaction:R-HSA-417898] P2Y4 receptor can bind to UTP - Homo sapiens [Reaction:R-HSA-374758] Somatostatin receptors bind somatostatin and cortistatin - Homo sapiens [Reaction:R-HSA-420724] CASR binds Ca2+ - Homo sapiens [Reaction:R-HSA-444527] FPR is a receptor for formyl peptides - Homo sapiens [Reaction:R-HSA-391913] FPR2 binds FPR2 ligands - Homo sapiens [Reaction:R-HSA-444476] FPRL2 receptor binds a wide range of ligands - Homo sapiens [Reaction:R-HSA-444848] Relaxin 3 receptor 1 binds relaxin 3 - Homo sapiens [Reaction:R-HSA-444859] Relaxin 3 receptor 2 binds relaxin 3 and INSL5 - Homo sapiens [Reaction:R-HSA-517536] N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine - Homo sapiens [Reaction:R-HSA-947673] Melanin-concentrating hormone receptors bind MCH - Homo sapiens [Reaction:R-HSA-981832] NMUR2 binds neuromedin-S - Homo sapiens [Reaction:R-HSA-964800] Neuromedin-U receptors bind neuromedins U, S - Homo sapiens [Reaction:R-HSA-3296233] T2Rs bind bitter-tasting compounds - Homo sapiens [Reaction:R-HSA-964773] OXGR1 binds 2OG - Homo sapiens [Reaction:R-HSA-3296244] SUCNR1 binds SUCCA - Homo sapiens [Reaction:R-HSA-3296326] HCAR1 binds LACT - Homo sapiens [Reaction:R-HSA-444661] HCAR2 binds HCAR2 ligands - Homo sapiens [Reaction:R-HSA-3296309] HCAR3 binds HCAR3 ligands - Homo sapiens [Reaction:R-HSA-373342] CX3CR1 binds CX3CL1 - Homo sapiens [Reaction:R-HSA-8862733] CCR2, CCR3 bind CCL13 - Homo sapiens [Reaction:R-HSA-8851352] CCR8 binds CCL1 - Homo sapiens [Reaction:R-HSA-8851679] GPR183 binds 7alpha,25-dihydroxycholesterol - Homo sapiens [Reaction:R-HSA-5336182] GPR37 binds prosaptide - Homo sapiens [Reaction:R-HSA-5336184] GPR37L binds prosaposin - Homo sapiens [Reaction:R-HSA-3296304] GPR31 is a receptor for 12(S)-HETE - Homo sapiens [Reaction:R-HSA-420688] GABAB heterodimeric receptor binds GABA - Homo sapiens [Reaction:R-HSA-444705] T1R1/T1R3 dimer is the umami taste receptor - Homo sapiens [Reaction:R-HSA-444606] T1R2/T1R3 dimer is a sweet taste receptor - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:782850] D'Eustachio, P, 2010-05-21
revised	[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-749456
summation	[Summation:380125] Many unrelated GPCRs couple with the Gi G-protein subtype. T...

Referrals

(precedingEvent)	[Reaction:R-HSA-380073] Liganded Gi-activating GPCR acts as a GEF for Gi
(hasEvent)	[Pathway:R-HSA-418594] G alpha (i) signalling events

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