Reactome | Receptors CXCR4 and 7 bind CXCL12 ligand

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Receptors CXCR4 and 7 bind CXCL12 ligand Show undefined attributes

authored	[InstanceEdit:375275] Jassal, Bijay, 2008-08-21
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:374171] Jassal, Bijay, 2008-07-28
dbId	374214
displayName	Receptors CXCR4 and 7 bind CXCL12 ligand
edited	[InstanceEdit:375493] D'Eustachio, P, 2008-09-01 11:58:31
eventOf	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines - Homo sapiens
followingEvent	[Reaction:R-HSA-8986258] SLIT2:ROBO1 binds CXCR4 - Homo sapiens [Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2980693] CXCL12(22-93) [extracellular region] [DefinedSet:R-HSA-374120] CXCR4,7 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:374164] Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor [LiteratureReference:374137] The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Receptors CXCR4 and 7 bind CXCL12 ligand
orthologousEvent	[Reaction:R-GGA-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Gallus gallus [Reaction:R-DRE-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Danio rerio [Reaction:R-SSC-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Sus scrofa [Reaction:R-RNO-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Rattus norvegicus [Reaction:R-MMU-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Mus musculus
output	[Complex:R-HSA-374203] CXCR4,7:CXCL12 [plasma membrane]
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:375494] Bockaert, J, 2008-09-01 12:04:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-374214
summation	[Summation:374139] CXCL12 (stromal cell-derived factor-1, SDF-1) (Shirozu M et ...
updateTrackers	[UpdateTracker:9787634] Update Tracker - [Reaction:374214] Receptors CXCR4 and 7 bind CXCL12 ligand - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787634] Update Tracker - [Reaction:374214] Receptors CXCR4 and 7 bind CXCL12 ligand - v44:[add_removeInput]
(precedingEvent)	[Reaction:R-HSA-8986258] SLIT2:ROBO1 binds CXCR4 [Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(hasEvent)	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines