Reactome | Receptor CXCR2 binds ligands CXCL1 to 7

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Receptor CXCR2 binds ligands CXCL1 to 7 Show undefined attributes

authored	[InstanceEdit:375275] Jassal, Bijay, 2008-08-21
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:373768] Jassal, Bijay, 2008-07-17
dbId	373813
displayName	Receptor CXCR2 binds ligands CXCL1 to 7
edited	[InstanceEdit:375493] D'Eustachio, P, 2008-09-01 11:58:31
eventOf	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines - Homo sapiens
followingEvent	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-373796] CXCR2 [plasma membrane] [DefinedSet:R-HSA-373814] CXCR2 ligands [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:373799] Cloning of complementary DNA encoding a functional human interleukin-8 receptor [LiteratureReference:373781] Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin [LiteratureReference:373793] Identification of three related human GRO genes encoding cytokine functions [LiteratureReference:373820] Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue [LiteratureReference:373810] Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line [LiteratureReference:373849] Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8 [LiteratureReference:373795] Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Receptor CXCR2 binds ligands CXCL1 to 7
orthologousEvent	[Reaction:R-GGA-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Gallus gallus [Reaction:R-DRE-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Danio rerio [Reaction:R-SSC-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Sus scrofa [Reaction:R-BTA-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Bos taurus [Reaction:R-CFA-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Canis familiaris [Reaction:R-RNO-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Rattus norvegicus [Reaction:R-MMU-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Mus musculus
output	[Complex:R-HSA-373773] CXCR2:CXCR2 ligands [plasma membrane]
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:375494] Bockaert, J, 2008-09-01 12:04:13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373813
summation	[Summation:373788] CXCR2 (High affinity interleukin-8 receptor B) (Murphy PM an...

Referrals

(hasEvent)	[Pathway:R-HSA-380108] Chemokine receptors bind chemokines
(precedingEvent)	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

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