Reactome | Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

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Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020772
displayName	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
eventOf	[Pathway:R-MMU-418594] G alpha (i) signalling events - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Mus musculus
inferredFrom	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[Complex:R-MMU-392165] Heterotrimeric G-protein Gi (inactive) [plasma membrane] [DefinedSet:R-MMU-380091] Ligand:GPCR complexes that activate Gi [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
output	[Complex:R-MMU-749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane]
precedingEvent	[Reaction:R-MMU-374173] AGT(25-32) binds to AGTR1 - Mus musculus [Reaction:R-MMU-9615348] AGT(25-32) binds to AGTR2 - Mus musculus [Reaction:R-MMU-374337] Apelin receptor binds to apelin - Mus musculus [Reaction:R-MMU-374331] Bradykinin receptors B1 and B2 bind to bradykinin - Mus musculus [Reaction:R-MMU-444647] C3a receptor binds anaphylatoxin C3a - Mus musculus [Reaction:R-MMU-375395] C5a receptor binds C5a anaphylatoxin - Mus musculus [Reaction:R-MMU-374207] G protein-coupled estrogen receptor 1 binds estrogen non-classically - Mus musculus [Reaction:R-MMU-374787] GPCR neuropeptide receptor binds neuropeptides B and W - Mus musculus [Reaction:R-MMU-374723] Nociceptin receptor binds to nociceptin - Mus musculus [Reaction:R-MMU-374298] Opioid receptors bind opioid peptides - Mus musculus [Reaction:R-MMU-444523] CXCR5 binds CXCL13 - Mus musculus [Reaction:R-MMU-373791] Receptor CXCR1 binds CXCL6 and CXCL8 ligands - Mus musculus [Reaction:R-MMU-373813] Receptor CXCR2 binds ligands CXCL1 to 7 - Mus musculus [Reaction:R-MMU-374248] Receptor CXCR3 binds ligands CXCL9 to 11 - Mus musculus [Reaction:R-MMU-373358] Receptor CXCR6 binds CXCL16 ligand - Mus musculus [Reaction:R-MMU-374214] Receptors CXCR4 and 7 bind CXCL12 ligand - Mus musculus [Reaction:R-MMU-373086] Receptor CCR10 binds CCL27 and 28 ligands - Mus musculus [Reaction:R-MMU-373087] Receptor CCR6 binds CCL20 ligand - Mus musculus [Reaction:R-MMU-373071] Receptor CCR7 binds CCL19 and 21 ligands - Mus musculus [Reaction:R-MMU-373074] Receptor CCR9 binds CCL25 ligand - Mus musculus [Reaction:R-MMU-373061] Receptors CCR3, 4 and 5 bind CCL5 ligand - Mus musculus [Reaction:R-MMU-390929] HTR1 and 5A receptors can bind serotonin - Mus musculus [Reaction:R-MMU-418904] A1 and A3 receptors bind adenosine - Mus musculus [Reaction:R-MMU-419426] Cannabinoid receptors can bind cannabinoids - Mus musculus [Reaction:R-MMU-390846] D2D3,4 bind to DA - Mus musculus [Reaction:R-MMU-390886] HRH4 binds Hist - Mus musculus [Reaction:R-MMU-390673] CHRM2,4 bind acetylcholine - Mus musculus [Reaction:R-MMU-417829] P2RY12 binds ADP - Mus musculus [Reaction:R-MMU-417843] P2Y13 binds ADP - Mus musculus [Reaction:R-MMU-417858] P2Y14 receptor can bind to UDP-glucose - Mus musculus [Reaction:R-MMU-417898] P2Y4 receptor can bind to UTP - Mus musculus [Reaction:R-MMU-374758] Somatostatin receptors bind somatostatin and cortistatin - Mus musculus [Reaction:R-MMU-420724] CASR binds Ca2+ - Mus musculus [Reaction:R-MMU-444527] FPR is a receptor for formyl peptides - Mus musculus [Reaction:R-MMU-391913] FPR2 binds FPR2 ligands - Mus musculus [Reaction:R-MMU-444476] FPRL2 receptor binds a wide range of ligands - Mus musculus [Reaction:R-MMU-444848] Relaxin 3 receptor 1 binds relaxin 3 - Mus musculus [Reaction:R-MMU-444859] Relaxin 3 receptor 2 binds relaxin 3 and INSL5 - Mus musculus [Reaction:R-MMU-517536] N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine - Mus musculus [Reaction:R-MMU-947673] Melanin-concentrating hormone receptors bind MCH - Mus musculus [Reaction:R-MMU-981832] NMUR2 binds neuromedin-S - Mus musculus [Reaction:R-MMU-964800] Neuromedin-U receptors bind neuromedins U, S - Mus musculus [Reaction:R-MMU-3296233] T2Rs bind bitter-tasting compounds - Mus musculus [Reaction:R-MMU-964773] OXGR1 binds 2OG - Mus musculus [Reaction:R-MMU-3296244] SUCNR1 binds SUCCA - Mus musculus [Reaction:R-MMU-3296326] HCAR1 binds LACT - Mus musculus [Reaction:R-MMU-444661] HCAR2 binds HCAR2 ligands - Mus musculus [Reaction:R-MMU-3296309] HCAR3 binds HCAR3 ligands - Mus musculus [Reaction:R-MMU-373342] CX3CR1 binds CX3CL1 - Mus musculus [Reaction:R-MMU-8862733] CCR2, CCR3 bind CCL13 - Mus musculus [Reaction:R-MMU-8851352] CCR8 binds CCL1 - Mus musculus [Reaction:R-MMU-8851679] GPR183 binds 7alpha,25-dihydroxycholesterol - Mus musculus [Reaction:R-MMU-5336182] GPR37 binds prosaptide - Mus musculus [Reaction:R-MMU-5336184] GPR37L binds prosaposin - Mus musculus [Reaction:R-MMU-3296304] GPR31 is a receptor for 12(S)-HETE - Mus musculus [Reaction:R-MMU-420688] GABAB heterodimeric receptor binds GABA - Mus musculus [Reaction:R-MMU-444705] T1R1/T1R3 dimer is the umami taste receptor - Mus musculus [Reaction:R-MMU-444606] T1R2/T1R3 dimer is a sweet taste receptor - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-749456
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-380073] Liganded Gi-activating GPCR acts as a GEF for Gi
(inferredTo)	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(hasEvent)	[Pathway:R-MMU-418594] G alpha (i) signalling events

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