Reactome | HTR1 and 5A receptors can bind serotonin

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HTR1 and 5A receptors can bind serotonin Show undefined attributes

authored	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
dbId	390929
displayName	HTR1 and 5A receptors can bind serotonin
edited	[InstanceEdit:390928] Jassal, Bijay, 2009-02-12
eventOf	[Pathway:R-HSA-390666] Serotonin receptors - Homo sapiens
followingEvent	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Homo sapiens
input	[SimpleEntity:R-ALL-114523] 5HT [extracellular region] [DefinedSet:R-HSA-390959] HTR1B,D,E,F,HTR5A [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:390945] Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes [LiteratureReference:390981] Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity [LiteratureReference:390946] Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta [LiteratureReference:390950] Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor [LiteratureReference:391043] Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase [LiteratureReference:391006] Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family [LiteratureReference:374957] The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	HTR1 and 5A receptors can bind serotonin
orthologousEvent	[Reaction:R-CEL-390929] HTR1 and 5A receptors can bind serotonin - Caenorhabditis elegans [Reaction:R-DME-390929] HTR1 and 5A receptors can bind serotonin - Drosophila melanogaster [Reaction:R-GGA-390929] HTR1 and 5A receptors can bind serotonin - Gallus gallus [Reaction:R-XTR-390929] HTR1 and 5A receptors can bind serotonin - Xenopus tropicalis [Reaction:R-DRE-390929] HTR1 and 5A receptors can bind serotonin - Danio rerio [Reaction:R-SSC-390929] HTR1 and 5A receptors can bind serotonin - Sus scrofa [Reaction:R-BTA-390929] HTR1 and 5A receptors can bind serotonin - Bos taurus [Reaction:R-CFA-390929] HTR1 and 5A receptors can bind serotonin - Canis familiaris [Reaction:R-RNO-390929] HTR1 and 5A receptors can bind serotonin - Rattus norvegicus [Reaction:R-MMU-390929] HTR1 and 5A receptors can bind serotonin - Mus musculus
output	[Complex:R-HSA-390955] HTR1B,D,E,F,HTR5A:5HT [plasma membrane]
precedingEvent	[Reaction:R-HSA-380901] Release of docked serotonin loaded synaptic vesicle - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392262] D'Eustachio, P, 2009-03-02 09:24:35
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-390929
summation	[Summation:391038] 5-hydroxytryptamine receptors (HTRs), once bound to serotoni...
updateTrackers	[UpdateTracker:9791389] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v30:[add_removeInput] [UpdateTracker:9776707] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v74:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791389] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v30:[add_removeInput] [UpdateTracker:9776707] Update Tracker - [Reaction:390929] HTR1 and 5A receptors can bind serotonin - v74:[modifyText]
(hasEvent)	[Pathway:R-HSA-390666] Serotonin receptors
(precedingEvent)	[Reaction:R-HSA-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

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